113965-37-0

Basic information

• Product Name: (R)-1-((S)-1-Phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester
• Synonyms: (R)-1-((S)-1-Phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester
• CAS NO: 113965-37-0
• Molecular Weight: 247.337
• Mol File: 113965-37-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-((S)-1-Phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-((S)-1-Phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester(113965-37-0)
• EPA Substance Registry System: (R)-1-((S)-1-Phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester(113965-37-0)

Safety Data

• Hazardous Substances Data: 113965-37-0(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 791638-41-0 5-Oxopentansaeure-methyl-ester 
• 25662-28-6 1-(carboxymethoxy)cyclopentadiene 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 
• 1560-11-8 cyclopent-1-enecarboxylic acid 

Downstream Products

• 1723-00-8 (R)-(+)-pipecolic acid 
• 28697-07-6 (R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 
• 35677-83-9 (+)-2R-Piperidine-2-carboxylic acid methyl ester 

Relevant articles and documents

An Asymmetric Synthesis of 2-Substituted Piperidines through Ozonolysis of Cyclopentenes and Reductive Aminocyclization

By the action of ozone, sodium cyanoborohydride and the optically active benzylic amines 2, the 1-substituted cyclopentenes 1, 5 and 9 were converted to a diastereometric mixture of 1,2-disubstituted piperidines (3, 6 and 10), respectively.Hydrogenation of these compounds and the following work-up yielded optically active 2-alkylpiperidines (4, up to 68percente.e.), pipecolic acid (7, 84percent e.e.) and 2-(hydroxymethyl)piperidine (11, up to 85percente.e.).Chromatographic separation of the major isomers of 3b and 6 enabled optically pure coniine (4b) and pipecolic acid (7) to be prepared, respectively.