113994-36-8 Usage
Uses
Used in Pharmaceutical Industry:
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3-pyridinecarboxylic acid ethyl ester is used as an intermediate in the preparation of amlodipine, a widely prescribed calcium channel blocker used for the treatment of hypertension, angina, and coronary artery disease. Its role in the synthesis of amlodipine is crucial, as it contributes to the formation of the final drug's active pharmaceutical ingredient (API).
As an intermediate in the synthesis of other pharmaceuticals, 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3-pyridinecarboxylic acid ethyl ester may also find applications in the development of new drugs targeting various medical conditions. Its unique structural features, such as the presence of the aminoethoxymethyl group and the chlorophenyl moiety, can be exploited to design and synthesize novel therapeutic agents with improved pharmacological properties and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 113994-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,9,9 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 113994-36:
(8*1)+(7*1)+(6*3)+(5*9)+(4*9)+(3*4)+(2*3)+(1*6)=138
138 % 10 = 8
So 113994-36-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H21ClN2O3/c1-3-24-18(22)17-14(13-6-4-5-7-15(13)19)10-12(2)21-16(17)11-23-9-8-20/h4-7,10H,3,8-9,11,20H2,1-2H3
113994-36-8Relevant academic research and scientific papers
Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine / confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry
Beresford,Macrae,Alker,Kobylecki
, p. 201 - 209 (2007/10/02)
Metabolism of the dihydropyridine calcium antagonist (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5 methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) has been studied in animals and man using 14C-labelled drug. The metabolite patterns are complex; 18 metabolites have been isolated from rat, dog and human urine. Based on chromatographic and mass-spectral evidence, structures have been proposed for the main metabolites and confirmed by synthesis of unambiguous reference compounds.
