113994-36-8

Basic information

• Product Name: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3-pyridinecarboxylic acid ethyl ester
• Synonyms: Amlodipine related compound A;2-[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYL-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;ETHYL 2-((2-AMINOETHOXY)METHYL)-4-(2-CHLOROPHENYL)-6-METHYLNICOTINATE
• CAS NO: 113994-36-8
• Molecular Formula: C18H21ClN2O3
• Molecular Weight: 348.82
• Product Categories: Amlodipine
• Mol File: 113994-36-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 461.8 °C at 760 mmHg
• Flash Point: 233.1 °C
• Appearance: /
• Density: 1.203
• Refractive Index: 1.565
• Storage Temp.: 2-8°C
• PKA: 8.46±0.10(Predicted)
• CAS DataBase Reference: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3-pyridinecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3-pyridinecarboxylic acid ethyl ester(113994-36-8)
• EPA Substance Registry System: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3-pyridinecarboxylic acid ethyl ester(113994-36-8)

Safety Data

• Hazardous Substances Data: 113994-36-8(Hazardous Substances Data)

Usage

Uses

Ethyl 2-?((2-?Aminoethoxy)?methyl)?-?4-?(2-?chlorophenyl)?-?6-?methylnicotinate is an intermediate in the preparation of amlodipine.

InChI:InChI=1/C18H21ClN2O3/c1-3-24-18(22)17-14(13-6-4-5-7-15(13)19)10-12(2)21-16(17)11-23-9-8-20/h4-7,10H,3,8-9,11,20H2,1-2H3

Upstream product

• 120289-14-7 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 120300-95-0 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 120289-15-8 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 88150-45-2 ethyl 4-(2-azidoethoxy)acetoacetate 
• 89-98-5 2-chloro-benzaldehyde 
• 120300-97-2 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methylpyridine 

Relevant articles and documents

Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine / confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry

Metabolism of the dihydropyridine calcium antagonist (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5 methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) has been studied in animals and man using 14C-labelled drug. The metabolite patterns are complex; 18 metabolites have been isolated from rat, dog and human urine. Based on chromatographic and mass-spectral evidence, structures have been proposed for the main metabolites and confirmed by synthesis of unambiguous reference compounds.