114-32-9

Basic information

• Product Name: (2-ethylphenyl)urea
• Synonyms: (2-ethylphenyl)urea;1-(2-Ethylphenyl)urea
• CAS NO: 114-32-9
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.20438
• EINECS: 204-045-9
• Mol File: 114-32-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 142-143 °C
• Boiling Point: 267.6°Cat760mmHg
• Flash Point: 115.7°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.00807mmHg at 25°C
• Refractive Index: 1.603
• PKA: 14.53±0.50(Predicted)
• CAS DataBase Reference: (2-ethylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: (2-ethylphenyl)urea(114-32-9)
• EPA Substance Registry System: (2-ethylphenyl)urea(114-32-9)

Safety Data

• Hazardous Substances Data: 114-32-9(Hazardous Substances Data)

Usage

General Description

(2-ethylphenyl)urea, also known as N-(2-ethylphenyl)urea, is a chemical compound that belongs to the class of urea derivatives. It is a white crystalline solid that is slightly soluble in water and soluble in organic solvents. (2-ethylphenyl)urea is used in various industrial and pharmaceutical applications, including as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. It also has potential biological activity, and its derivatives may be explored for their medicinal properties. However, like any chemical, it should be handled and used with proper care and safety precautions to avoid any potential hazards.

InChI:InChI=1/C9H12N2O/c1-2-7-5-3-4-6-8(7)11-9(10)12/h3-6H,2H2,1H3,(H3,10,11,12)

Upstream product

• 590-28-3 potassium cyanate 
• 578-54-1 ortho-ethylaniline 
• 917-61-3 sodium isocyanate 

Downstream Products

• 143028-44-8 3-(2-Ethyl-phenyl)-10-p-tolyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 143028-59-5 3-(2-Ethyl-phenyl)-6-p-tolylamino-1H-pyrimidine-2,4-dione 
• 83315-93-9 1-{2-[6,8-Dibromo-3-(3-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylsulfanyl]-acetyl}-3-(2-ethyl-phenyl)-urea 
• 83380-52-3 1-{2-[6,8-Dibromo-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylsulfanyl]-acetyl}-3-(2-ethyl-phenyl)-urea 
• 83315-84-8 1-[2-(6,8-Dibromo-4-oxo-3-o-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetyl]-3-(2-ethyl-phenyl)-urea 
• 189211-43-6 6-(tert-butylanilino)-3-(2-ethylphenyl)uracil 
• 142940-86-1 6-chloro-3-(2-ethylphenyl)uracil 
• 142940-81-6 1-(2-ethylphenyl)pyrimidine-2,4,6-(1H,3H,5H)-trione 
• 58351-87-4 1-chloroacetyl-3-(2-ethyl-phenyl)-urea 

Relevant articles and documents

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

Small molecule inhibitors of pre-mRNA splicing are important tools for identifying new spliceosome assembly intermediates, allowing a finer dissection of spliceosome dynamics and function. Here, we identified a small molecule that inhibits human pre-mRNA splicing at an intermediate stage during conversion of pre-catalytic spliceosomal B complexes into activated Bact complexes. Characterization of the stalled complexes (designated B028) revealed that U4/U6 snRNP proteins are released during activation before the U6 Lsm and B-specific proteins, and before recruitment and/or stable incorporation of Prp19/CDC5L complex and other Bact complex proteins. The U2/U6 RNA network in B028 complexes differs from that of the Bact complex, consistent with the idea that the catalytic RNA core forms stepwise during the B to Bact transition and is likely stabilized by the Prp19/CDC5L complex and related proteins. Taken together, our data provide new insights into the RNP rearrangements and extensive exchange of proteins that occurs during spliceosome activation.