114-79-4

Basic information

• Product Name: N-(3,4-DIMETHYLPHENYL)UREA
• Synonyms: Zinc00394977
• CAS NO: 114-79-4
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 0
• Mol File: 114-79-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 274.5°C at 760 mmHg
• Flash Point: 119.8°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 0.00537mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: N-(3,4-DIMETHYLPHENYL)UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-DIMETHYLPHENYL)UREA(114-79-4)
• EPA Substance Registry System: N-(3,4-DIMETHYLPHENYL)UREA(114-79-4)

Safety Data

• Hazardous Substances Data: 114-79-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12N2O/c1-6-3-4-8(5-7(6)2)11-9(10)12/h3-5H,1-2H3,(H3,10,11,12)

Upstream product

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Relevant articles and documents

Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents

A series of novel hydantoin-bridged analogues of combretastatin A-4 (CA-4) were designed, synthesized and evaluated for antiproliferative activities in vitro and in vivo. The most potent compound 8d, showed potent cytotoxicity against four human cancer cell lines with IC50 values of 0.186–0.279 μM, and possessed the efficacy of inhibiting tubulin polymerization, disrupting in vitro vascularization, blocking cell cycle in G2/M phase and inducing cell apoptosis. In the nude mice xenograft model, 8d significantly inhibited the tumor growth and showed low toxicity. Further chiral separation proved (R)-(?)-8d to be the preferential enantiomer with IC50 values of 0.081–0.157 M. These results indicated that the hydantoin derivatives merit further investigation as potential anticancer agents that inhibit tubulin polymerization.