114003-10-0

Basic information

• Product Name: 3'-methyl-N-(p-tolyl)-[1,1'-biphenyl]-2-carboxamide
• Synonyms: 3'-methyl-N-(p-tolyl)-[1,1'-biphenyl]-2-carboxamide
• CAS NO: 114003-10-0
• Molecular Weight: 301.388
• Mol File: 114003-10-0.mol

Chemical Properties

• CAS DataBase Reference: 3'-methyl-N-(p-tolyl)-[1,1'-biphenyl]-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-methyl-N-(p-tolyl)-[1,1'-biphenyl]-2-carboxamide(114003-10-0)
• EPA Substance Registry System: 3'-methyl-N-(p-tolyl)-[1,1'-biphenyl]-2-carboxamide(114003-10-0)

Safety Data

• Hazardous Substances Data: 114003-10-0(Hazardous Substances Data)

Upstream product

• 19562-37-9 3-(4-methylphenyl)benzo-1,2,3-triazin-4(3H)-one 
• 17933-03-8 m-tolylboronic acid 

Relevant articles and documents

Nickel-Catalyzed Denitrogenative ortho-Arylation of Benzotriazinones with Organic Boronic Acids: an Efficient Route to Losartan and Irbesartan Drug Molecules

Denitrogenative ortho-arylation, vinylation and methylation of 1,2,3-benzotriazin-4-(3H)-ones with organic boronic acids catalyzed by nickel complexes to give a wide range of o-substituted benzamides were demonstrated. Further, the catalytic reaction is successfully applied to the synthesis of the popular hypertensive drugs losartan and irbesartan in high yields. (Figure presented.).