114019-02-2Relevant academic research and scientific papers
An Examination of O-2-Isocephems as Orally Absorbable Antibiotics
Mastalerz, Harold,Menard, Marcel,Vinet, Vivianne,Desiderio, James,Fung-Tomc, Joan,et al.
, p. 1190 - 1196 (1988)
The synthesis and structure-activity relationships of a series of orally absorbed O-2-isocephems are described.These compounds possessed a D-amino substituent at the 7-position while the substituent at the 3-position was varied.Relative to the analogous cephems, the O-2-isocephems exhibited comparable to better activity against Gram-positive organisms.Against Gram-negative organisms, their activity was variable but did indicate a lower β-lactamase stability.Following oral administration, the O-2-isocephems generally exhibited longer half-lives but lower Cmax's and urinary recoveries.
