114021-22-6

Basic information

• Product Name: 3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-O4-(2,4,6-TRIISOPROPYL-PHENYLSULFONYL)THYMIDINE
• Synonyms: 3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-O4-(2,4,6-TRIISOPROPYL-PHENYLSULFONYL)THYMIDINE
• CAS NO: 114021-22-6
• Molecular Formula: C₃₇H₆₄N₂O₇SSi₂
• Molecular Weight: 737.15
• Mol File: 114021-22-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-O4-(2,4,6-TRIISOPROPYL-PHENYLSULFONYL)THYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-O4-(2,4,6-TRIISOPROPYL-PHENYLSULFONYL)THYMIDINE(114021-22-6)
• EPA Substance Registry System: 3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-O4-(2,4,6-TRIISOPROPYL-PHENYLSULFONYL)THYMIDINE(114021-22-6)

Safety Data

• Hazardous Substances Data: 114021-22-6(Hazardous Substances Data)

Upstream product

• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 50-89-5 thymidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 

Downstream Products

• 1290537-73-3 C₄₃H₅₂N₅O₇PS 
• 869355-26-0 C₁₃H₁₇N₃O₄S 
• 142409-74-3 5'-O-(4,4'-Dimethoxytrityl)-4--thiothymidine 
• 1422258-31-8 C₅₀H₆₉N₄O₇PS 
• 1422258-30-7 C₄₁H₅₂N₂O₆S 
• 944149-08-0 1-[2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)ribofuranosyl]-4-phenyl-5-methyl-2-(1H)-pyrimidinone 
• 124575-05-9 2,4,6-Triisopropyl-benzenesulfonic acid 1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5,6-dimethyl-2-oxo-1,2,3,6-tetrahydro-pyrimidin-4-yl ester 

Relevant articles and documents

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

Mind over matter: LC-MS has allowed the amount of the post-replicatively formed DNA base 5hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is most abundant in areas that are associated with higher cognitive functions, and its content in mouse hippocampi seems to increase with age. The new method enables hydroxymethylcytosine to be quantified with unprecedented accuracy. (Figure Presented)

Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups

The consecutive arrangement of 2′-deoxy-6-thioguanosines (s 6Gs) and 4-thiothymidines (s4Ts) in antiparallel triplex-forming oligonucleotides (TFOs) considerably stabilized the resulting antiparallel triplexes with high base recognit