1140240-20-5Relevant articles and documents
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1
Hornberger, Keith R.,Berger, Dan M.,Crew, Andrew P.,Dong, Hanqing,Kleinberg, Andrew,Li, An-Hu,Medeiros, Matthew R.,Mulvihill, Mark J.,Siu, Kam,Tarrant, James,Wang, Jing,Weng, Felix,Wilde, Victoria L.,Albertella, Mark,Bittner, Mark,Cooke, Andrew,Gray, Michael J.,Maresca, Paul,May, Earl,Meyn, Peter,Peick Jr., William,Romashko, Darlene,Tanowitz, Michael,Tokar, Brianna
, p. 4517 - 4522 (2013)
The discovery and potency optimization of a series of 7-aminofuro[2,3-c] pyridine inhibitors of TAK1 is described. Micromolar hits taken from high-throughput screening were optimized for biochemical and cellular mechanistic potency to ～10 nM, as exemplified by compound 12az. Application of structure-based drug design aided by co-crystal structures of TAK1 with inhibitors significantly shortened the number of iterations required for the optimization.
