1140495-89-1 Usage
General Description
The chemical "1-Pyrrolidinecarboxylic acid, 2-[4-[(4-chlorophenyl)Methyl]-5-Methyl-4H-1,2,4-triazol-3-yl]-, 1,1-diMethylethyl ester, (2R)-" is a compound that is commonly known as the antifungal medication Itraconazole. It belongs to the class of triazole antifungal medications and is used to treat various fungal infections, including those affecting the skin, nails, and internal organs. Itraconazole works by inhibiting the growth of fungi and is available in various forms such as capsules, oral solutions, and injections. It is important to use Itraconazole under the guidance of a healthcare professional due to its potential side effects and interactions with other medications.
Check Digit Verification of cas no
The CAS Registry Mumber 1140495-89-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,0,4,9 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1140495-89:
(9*1)+(8*1)+(7*4)+(6*0)+(5*4)+(4*9)+(3*5)+(2*8)+(1*9)=141
141 % 10 = 1
So 1140495-89-1 is a valid CAS Registry Number.
1140495-89-1Relevant articles and documents
Novel pyrrolidine heterocycles as CCR1 antagonists
Merritt, J. Robert,James, Ray,Paradkar, Vidyadhar M.,Zhang, Chongwu,Liu, Ruiyan,Liu, Jinqi,Jacob, Biji,Chiriac, Camelia,Ohlmeyer, Michael J.,Quadros, Elizabeth,Wines, Pamela,Postelnek, Jennifer,Hicks, Catherine M.,Chen, Weiqing,Kimble, Earl F.,O'Brien, Linda,White, Nicole,Desai, Hema,Appell, Kenneth C.,Webb, Maria L.
supporting information; experimental part, p. 5477 - 5479 (2010/12/24)
A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptab