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1140496-05-4

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1140496-05-4 Usage

General Description

(S)-7-(Trifluoromethyl)chroman-4-amine is a chemical compound with the molecular formula C10H10F3NO that contains a chromane core structure with a trifluoromethyl group attached to the 7th position and an amine group at the 4th position. It is a chiral compound with a stereocenter, meaning it exists as a pair of enantiomers. This chemical has potential applications in pharmaceutical research and drug development due to its unique structure and the presence of a triflufloromethyl group, which can influence the compound's chemical and biological properties. It may be used in the synthesis of various pharmaceutical compounds or as a building block for other organic molecules. Further studies are needed to explore its potential uses and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1140496-05-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,0,4,9 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1140496-05:
(9*1)+(8*1)+(7*4)+(6*0)+(5*4)+(4*9)+(3*6)+(2*0)+(1*5)=124
124 % 10 = 4
So 1140496-05-4 is a valid CAS Registry Number.

1140496-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S)-7-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1140496-05-4 SDS

1140496-05-4Relevant articles and documents

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur

, p. 1338 - 1341 (2011/04/23)

Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.

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