1140530-92-2Relevant academic research and scientific papers
Synthesis of a novel glucose-conjugated 15-crown-5 ether with a spiro ketal structure
Yamanoi, Takashi,Oda, Yoshiki,Muraishi, Hitomi,Matsuda, Sho
, p. 1840 - 1845 (2008)
This paper describes a synthetic approach to a novel glucose-conjugated 15-crown-5 ether having a spiroketal structure starting from a 1-C-vinylated glucose derivative. The approach consists of the glycosylation of the vinylated glucose derivative to give an ethyleneoxy spacer derivative using bismuth(III) triflate, the conversion of the 1-C-vinyl group of the glucoside produced into a carboxylic acid group, and the intramolecular condensation between the carboxyl group and the terminal hydroxyl group in the ethyleneoxy spacer. A D-glucose-conjugated 15-crown-5 ether having a unique spiroketal structure was thus successfully synthesized.
