1140895-32-4

Basic information

• Product Name: (2R,3S,4R)-2-tert-butyl 2-methyl 1,4-dimethyl-5-oxo-3-((phenylselanyl)methyl)pyrrolidine-2,2-dicarboxylate
• Synonyms: (2R,3S,4R)-2-tert-butyl 2-methyl 1,4-dimethyl-5-oxo-3-((phenylselanyl)methyl)pyrrolidine-2,2-dicarboxylate
• CAS NO: 1140895-32-4
• Molecular Weight: 440.398
• Mol File: 1140895-32-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S,4R)-2-tert-butyl 2-methyl 1,4-dimethyl-5-oxo-3-((phenylselanyl)methyl)pyrrolidine-2,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4R)-2-tert-butyl 2-methyl 1,4-dimethyl-5-oxo-3-((phenylselanyl)methyl)pyrrolidine-2,2-dicarboxylate(1140895-32-4)
• EPA Substance Registry System: (2R,3S,4R)-2-tert-butyl 2-methyl 1,4-dimethyl-5-oxo-3-((phenylselanyl)methyl)pyrrolidine-2,2-dicarboxylate(1140895-32-4)

Safety Data

• Hazardous Substances Data: 1140895-32-4(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 1140895-31-3 (3R,3aS,6aR)-tert-butyl hexahydro-1,3-dimethyl-2,6-dioxo-1H-furo[3,4-b]pyrrole-6a-carboxylate 
• 1666-13-3 diphenyl diselenide 

Relevant articles and documents

Efficient asymmetric synthesis of the functionalized pyroglutamate core unit common to oxazolomycin and neooxazolomycin using Michael reaction of nucleophilic glycine Schiff base with α,β-disubstituted acrylate

The functionalized pyroglutamate core unit, (2R,4R)-3, which could be converted into the β-lactone/pyrrolidine or γ-lactone/pyrrolidine ring system of oxazolomycin A 1 and neooxazolomycin 2, and which possesses an exomethylene group at C3 as a scaffold for the construction of their C3 polyene segment, was synthesized by the Michael reaction of a glycine Schiff base 4 with the α,β-disubstituted acrylate 8 as the key step.