1140906-45-1Relevant articles and documents
A flexible approach to methyl (5S)-5-alkyltetramate derivatives
Jiang, Li-Jiao,Lan, Hong-Qiao,Zheng, Jian-Feng,Ye, Jian-Liang,Huang, Pei-Qiang
, p. 297 - 301 (2009)
Regioselective Grignard reagent additions to 3-methoxymaleimides and subsequent diastereoselective reductive dehydroxylation of the resulting N,O-acetals were studied. On the basis of these studies, a flexible and highly regio- and diastereoselective approach to methyl 5-alkyltetramate derivatives was disclosed. The method is the first direct and flexible asymmetric cationic synthon-based approach, and allows for the synthesis of various methyl (5S)-5-alkyltetramate derivatives that are otherwise inaccessible by the commonly used methods based on α-amino acids. Georg Thieme Verlag Stuttgart.