1140912-36-2Relevant academic research and scientific papers
Aminal-pyrrolidine organocatalysts - Highly efficient and modular catalysts for α-functionalization of carbonyl compounds
Quintard, Adrien,Belot, Sebastien,Marchai, Estelle,Alexakis, Alexandre
experimental part, p. 927 - 936 (2010/04/25)
The substitution of the 4-position of hydroxyproline by a phenol group, together with an aminal on the 2-position, gave a synergistic effect leading to two powerful complementary organocatalysts. They show excellent enantiocontrol in the α-functionalization of a wide range of linear/ branched aldehydes and ketones, including Michael additions to ethenediyl disulfones or nitrostyrene and α-amination. We obtained ees up to 98.5 % with low catalyst loadings (down to 1 mol-%). As a proof of efficiency, TOFs of up to 1000 h-1 could be obtained.
Highly enantioselective conjugate additions of aldehydes to vinyl sulfones
Landa, Aitor,Maestro, Miguel,Masdeu, Carme,Puente, Angel,Vera, Silvia,Oiarbide, Mikel,Palomo, Claudio
supporting information; experimental part, p. 1562 - 1565 (2009/10/01)
The use of less basic chiral amine catalysts for highly enantioselective conjugate additions of aldehydes to vinyl sulfones was reported. The results show that the addition of aldehydes to α-cyano vinyl sulfones takes place at -40°C to give alcohols. The
