1140912-44-2Relevant academic research and scientific papers
Bifunctional amino sulfonamide-catalyzed asymmetric conjugate addition to alkenyl alkynyl ketimines as enone surrogates
Homma, Chihiro,Kano, Taichi,Maruoka, Keiji
, p. 2808 - 2811 (2021)
A bifunctional amino sulfonamide-catalyzed asymmetric conjugate addition of aldehydes to alkenyl alkynyl ketimines as reactive surrogates for enones has been developed. Use of a phenylcyclopropane-based amino sulfonamide catalyst, which can activate and orient the ketimines through hydrogen bonding, affords the desired conjugate adducts with high chemo-, diastereo- and enantioselectivity.
Highly enantioselective conjugate additions of aldehydes to vinyl sulfones
Landa, Aitor,Maestro, Miguel,Masdeu, Carme,Puente, Angel,Vera, Silvia,Oiarbide, Mikel,Palomo, Claudio
supporting information; experimental part, p. 1562 - 1565 (2009/10/01)
The use of less basic chiral amine catalysts for highly enantioselective conjugate additions of aldehydes to vinyl sulfones was reported. The results show that the addition of aldehydes to α-cyano vinyl sulfones takes place at -40°C to give alcohols. The
