1140920-64-4Relevant academic research and scientific papers
C1-Symmetric aminosulfoximines in copper-catalyzed asymmetric vinylogous mukaiyama aldol reactions
Frings, Marcus,Atodiresei, Iuliana,Wang, Yutian,Runsink, Jan,Raabe, Gerhard,Bolm, Carsten
supporting information; experimental part, p. 4577 - 4587 (2010/08/19)
Vinylogous Mukaiyama-type aldol reactions have been catalyzed by a combination of Cu(OTf)2 and readily available C1-symmetric aminosulfoximines. After a fine-tuning of the reaction conditions and an optimization of the modularly assembled ligand structure, high stereoselectivities and excellent yields have been achieved in catalyzed reactions involving various electrophile/nucleophile combinations. The relative and absolute configurations of two products were assigned by X-ray single crystal structure analysis and a comparison of calculated and experimental CD spectra.
Catalyzed vinylogous Mukaiyama aldol reactions with controlled enantio-and diastereoselectivities
Frings, Marcus,Atodiresei, Iuliana,Runsink, Jan,Gerhard,Raabe,Bolm, Carsten
supporting information; experimental part, p. 1566 - 1569 (2009/10/02)
The applicability of various cyclic dienol silanes in combination with other ketonic substrates was examined by evaluating the substrate scope of the vinylogous Mukaiyama aldol reaction (VMAR). The substrate combinations afforded Mukaiyama aldol products
