1140969-69-2

Basic information

• Product Name: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea
• Synonyms: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea;N,N'-(1S,2S)-1,2-Cyclohexanediylbis[N'-[3,5- bis(trifluoromethyl)phenyl]thiourea],99%e.e.
• CAS NO: 1140969-69-2
• Molecular Formula: C₂₄H₂₀F₁₂N₄S₂
• Molecular Weight: 656.5532384
• Mol File: 1140969-69-2.mol

Chemical Properties

• Boiling Point: 504.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.46±0.70(Predicted)
• CAS DataBase Reference: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea(1140969-69-2)
• EPA Substance Registry System: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea(1140969-69-2)

Safety Data

• Hazardous Substances Data: 1140969-69-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
N,N'-(1S,2S)-1,2-cyclohexanediyl bis[n'-[3,5-bis(trifluoromethyl)phenyl)]-thiourea is used as a reagent in chemical reactions for its unique structural properties, facilitating the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N'-(1S,2S)-1,2-cyclohexanediyl bis[n'-[3,5-bis(trifluoromethyl)phenyl)]-thiourea is utilized for its potential applications in drug development, given its specific chemical structure that may contribute to the creation of new therapeutic agents.
Used in Agrochemical Industry:
N,N'-(1S,2S)-1,2-cyclohexanediyl bis[n'-[3,5-bis(trifluoromethyl)phenyl)]-thiourea also finds use in the agrochemical sector, where it may be employed in the development of new pesticides or other agricultural chemicals, leveraging its chemical properties to enhance crop protection and yield.

Upstream product

• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 

Relevant articles and documents

The influence of stereochemistry on anion binding and transport

Bis(thio)urea receptors (1-4) based on 1,2-bisaminocyclohexane are shown to function as transmembrane anion antiporters. The results show that cis-receptors have a greater propensity for anion transport than analogous trans-receptors. Stability constants using 1H NMR techniques highlight the significance of stereoisomerism on anion binding in solution, as cis-receptors bind anions more strongly than trans-receptors.

Thiourea catalyzed organocatalytic enantioselective Michael addition of diphenyl phosphite to nitroalkenes

Bifunctional thiourea catalyzes the enantioselective Michael addition reaction of diphenyl phosphite to nitroalkenes. This methodology provides a facile access to enantiomerically enriched β-nitrophosphonates, precursors for the preparation of synthetically and biologically useful β-aminophosphonic acids. DFT level of computational calculations invoke the attack of the diphenyl phosphite to the nitroolefin by the Re face, this give light to this scarcely explored process update in the literature. The computational calculations support the absolute configuration obtained in the final adducts.

A novel bis-thiourea organocatalyst for the asymmetric aza-Henry reaction

A novel bis-thiourea/2,2′-diaminobinaphthalene (BINAM)-based catalyst for the asymmetric aza-Henry reaction has been developed. This catalyst promotes the reaction of N-Boc imines with nitroalkanes to afford β-nitroamines with good yields and high enantioselectivities. This catalyst has the advantage that it can be prepared in a single step from commercially available materials. A model is proposed for the catalyst action where both components of the reaction are activated simultaneously by hydrogen bonding. Regardless of the mechanism, the success of the present catalyst demonstrates the potential of bis-thioureas as an interesting class of relatively unexplored catalysts.