1140969-69-2

Basic information

• Product Name: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea
• Synonyms: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea;N,N'-(1S,2S)-1,2-Cyclohexanediylbis[N'-[3,5- bis(trifluoromethyl)phenyl]thiourea],99%e.e.
• CAS NO: 1140969-69-2
• Molecular Formula: C₂₄H₂₀F₁₂N₄S₂
• Molecular Weight: 656.5532384
• Mol File: 1140969-69-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 504.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.46±0.70(Predicted)
• CAS DataBase Reference: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea(1140969-69-2)
• EPA Substance Registry System: N,N'-(1S,2S)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)]-Thiourea(1140969-69-2)

Safety Data

• Hazardous Substances Data: 1140969-69-2(Hazardous Substances Data)

Usage

General Description

N,N'-(1S,2S)-1,2-cyclohexanediyl bis[n'-[3,5-bis(trifluoromethyl)phenyl)]-thiourea is a chemical compound that belongs to the class of thioureas. It is a crystalline solid with the molecular formula C34H30F12N4S2 and a molecular weight of 794.74 g/mol. N,N'-(1S,2S)-1,2-cyclohexanediyl bis[n'-[3,5-bis(trifluoromethyl)phenyl)]-thiourea has applications in the field of chemistry, specifically in organic synthesis and as a reagent in chemical reactions. Its structure consists of a cyclohexanediyl backbone with two thiourea functional groups attached to it, each of which contains a 3,5-bis(trifluoromethyl)phenyl substituent. The compound has potential uses in pharmaceutical and agrochemical industries as well.

Upstream product

• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 
• 21436-03-3 (S,S)-1,2-diaminocyclohexane 

Relevant articles and documents

The influence of stereochemistry on anion binding and transport

Bis(thio)urea receptors (1-4) based on 1,2-bisaminocyclohexane are shown to function as transmembrane anion antiporters. The results show that cis-receptors have a greater propensity for anion transport than analogous trans-receptors. Stability constants using 1H NMR techniques highlight the significance of stereoisomerism on anion binding in solution, as cis-receptors bind anions more strongly than trans-receptors.

A novel bis-thiourea organocatalyst for the asymmetric aza-Henry reaction

A novel bis-thiourea/2,2′-diaminobinaphthalene (BINAM)-based catalyst for the asymmetric aza-Henry reaction has been developed. This catalyst promotes the reaction of N-Boc imines with nitroalkanes to afford β-nitroamines with good yields and high enantioselectivities. This catalyst has the advantage that it can be prepared in a single step from commercially available materials. A model is proposed for the catalyst action where both components of the reaction are activated simultaneously by hydrogen bonding. Regardless of the mechanism, the success of the present catalyst demonstrates the potential of bis-thioureas as an interesting class of relatively unexplored catalysts.