1140972-56-0Relevant academic research and scientific papers
Palladium-catalyzed asymmetric synthesis of allylic fluorides
Katcher, Matthew H.,Doyle, Abigail G.
, p. 17402 - 17404 (2011/02/23)
The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophilic fluorination, allowing access to highly enantioenriched cyclic allylic fluorides that bear diverse functional groups. Evidence that supports a mechanism in which C-F bond formation occurs by an SN2-type attack of fluoride on a Pd(II)-allyl intermediate is presented.
