114100-09-3 Usage
Uses
Used in Pharmaceutical Synthesis:
N-(3-aminomethyl-phenyl)-methanesulfonamide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex organic molecules, contributing to the development of new drugs with specific therapeutic targets.
Used in Chemical Research:
As a reagent, N-(3-aminomethyl-phenyl)-methanesulfonamide is utilized in chemical research to explore its properties and reactions, aiding in the advancement of organic chemistry and the discovery of novel chemical compounds.
Used in Drug Development:
N-(3-aminomethyl-phenyl)-methanesulfonamide is employed in the development of drugs targeting diverse biological pathways, potentially leading to treatments for a range of diseases by modulating specific molecular interactions within the body.
Used in Study of Drug-Receptor Interactions:
N-(3-AMINOMETHYL-PHENYL)-METHANESULFONAMIDE is used to investigate the binding and interaction mechanisms between drugs and their receptors, providing insights into the design of more effective and selective pharmaceutical agents.
Used in Organic Compound Preparation:
N-(3-aminomethyl-phenyl)-methanesulfonamide is an important building block in the preparation of organic compounds, facilitating the creation of new chemical entities with potential applications in various fields, including materials science and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 114100-09-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,1,0 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 114100-09:
(8*1)+(7*1)+(6*4)+(5*1)+(4*0)+(3*0)+(2*0)+(1*9)=53
53 % 10 = 3
So 114100-09-3 is a valid CAS Registry Number.
114100-09-3Relevant articles and documents
N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues: Novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor
Lee, Jeewoo,Lee, Jiyoun,Kang, Myungshim,Shin, Myoungyoup,Kim, Ji-Min,Kang, Sang-Uk,Lim, Ju-Ok,Choi, Hyun-Kyung,Suh, Young-Ger,Park, Hyeung-Geun,Oh, Uhtaek,Kim, Hee-Doo,Park, Young-Ho,Ha, Hee-Jin,Kim, Young-Ho,Toth, Attila,Wang, Yun,Tran, Richard,Pearce, Larry V.,Lundberg, Daniel J.,Blumberg, Peter M.
, p. 3116 - 3126 (2007/10/03)
Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells. In particular, compound 61, N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxypropyl]-N′-[3-fluoro-4- (methylsulfonylamino)benzyl]thiourea was a full antagonist against capsaicin, displayed a Ki value of 7.8 nM (compared to 520 nM for capsazepine and 4 nM for 5-iodoRTX), and showed excellent analgesic activity in mice. Structure-activity analysis of the influence of modifications in the A- and C-regions of 4-methylsulfonamide ligands on VR1 agonism/antagonism indicated that 3-fluoro substitution in the A-region and a 4-tert-butylbenzyl moiety in the C-region favored antagonism, whereas a 3-methoxy group in the A-region and 3-acyloxy2-benzylpropyl moieties in the C-region favored agonism.
