1141080-15-0

Basic information

• Product Name: 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one
• Synonyms: 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one;5-(3-Chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-;2H-Indol-2-one, 5-(3-chloro-4-fluorophenyl)-1,3-dihydro-3-methyl-3-(5-pyrimidinylmethyl)-1-(1H-1,2,4-triazol-5-yl)-;5-(3-chloro-4-fluorophenyl)-1,3-dihydro-3-methyl-3-(5-pyrimidinylmethyl)-1-(1H-1,2,4-triazol-5-yl)-2H-Indol-2-one;5-(3-Chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)indolin
• CAS NO: 1141080-15-0
• Molecular Formula: C₂₂H₁₆ClFN₆O
• Molecular Weight: 434.8534432
• Mol File: 1141080-15-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 659.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.451±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.33±0.20(Predicted)
• CAS DataBase Reference: 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one(1141080-15-0)
• EPA Substance Registry System: 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one(1141080-15-0)

Safety Data

• Hazardous Substances Data: 1141080-15-0(Hazardous Substances Data)

Usage

Description

5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one is an oxindoline derivative characterized by its complex molecular structure. It is a compound with a unique combination of functional groups, including a 3-chloro-4-fluorophenyl, a methyl, a pyrimidin-5-ylmethyl, and a 1H-1,2,4-triazol-3-yl group. This molecule is of interest due to its potential applications in various fields, particularly as a calcium channel blocker.

Uses

Used in Pharmaceutical Applications:
5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one is used as a calcium channel blocker for the treatment of various cardiovascular conditions. As a calcium channel blocker, it helps in regulating the flow of calcium ions into cardiac and vascular smooth muscle cells, which can lead to the relaxation of these muscles and a subsequent decrease in blood pressure. This makes it a valuable compound for the management of hypertension and other related cardiovascular diseases.
Used in Research and Development:
In the field of research and development, 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one serves as a valuable compound for studying the mechanisms of calcium channel blockers and their potential applications in medicine. Its unique structure allows researchers to explore new avenues in drug design and development, potentially leading to the discovery of more effective and targeted treatments for a range of conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, 5-(3-Chloro-4-fluorophenyl)-3-Methyl-3-(pyriMidin-5-ylMethyl)-1-(1H-1,2,4-triazol-3-yl)indolin-2-one can also be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By utilizing advanced drug delivery technologies, such as nanoparticles or liposomes, the compound can be more effectively targeted to specific cells or tissues, reducing side effects and improving overall treatment efficacy.

Upstream product

• 1141080-84-3 5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1-trityl-1,2,4-triazol-3yl)-1,3-dihydro-2H-indol-2-one 

Relevant articles and documents

N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

A series of N-substituted oxindole derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more othe