114125-58-5Relevant articles and documents
Rapid and convenient synthesis of aryl- and heteroaryl-α-hydroxy- α-trifluoromethyl acetate via Friedel-Crafts alkylation under solvent- and catalyst-free conditions
Zhao, Jun-Ling,Liu, Li,Zhang, Hai-Bo,Wu, Yan-Chao,Wang, Dong,Chen, Yong Jun
, p. 2511 - 2514 (2006)
Solvent- and catalyst-free Friedel-Crafts alkylation reactions of aromatic and heteroaromatic compounds with methyl trifluoropyruvate (2) were carried out at room temperature and finished in several minutes with good to excellent yields of the addition pr
Enantioselective Friedel-Crafts alkylation reactions catalyzed by a chiral nonracemic C2-symmetric 2,2′-bipyridyl copper(II) complex
Lyle, Michael P. A.,Draper, Neil D.,Wilson, Peter D.
, p. 901 - 904 (2005)
(Chemical Equation Presented) Enantioselective Friedel-Crafts alkylation reactions of a series of substituted indoles with methyl trifluoropyruvate, catalyzed by a chiral nonracemic C2-symmetric 2,2′-bipyridyl copper(II) triflate complex, are d
Cs2CO3-catalyzed alkylation of indoles with trifluoromethyl ketones
Liu, Xiao-Dong,Wang, Yi,Ma, Hai-Yan,Xing, Chun-Hui,Yuan, Yu,Lu, Long
, p. 2283 - 2289 (2017/03/24)
A Cs2CO3-catalyzed alkylation reaction of indoles with trifluoromethyl ketones was presented. Both alicyclic and aromatic trifluoromethyl ketones as well as various substituted indoles are compatible with the methodology. Good to excellent yields of the corresponding trifluoromethyl substituted tertiary alcohols 2,2,2-tritrifluoro-1-(1H-indol-3-yl)-ethan-1-ols were acquired as the sole products.
