114127-73-0

Basic information

• Product Name: [1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)cyclohexyl β-D-Glucopyranosiduronic Acid
• Synonyms: (1S,2R,5S)-(+)-Menthol β-D-Glucuronide;[1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)cyclohexyl β-D-Glucopyranosiduronic Acid
• CAS NO: 114127-73-0
• Molecular Formula: C₁₆H₂₈O₇
• Molecular Weight: 332.38932
• Product Categories: Chiral Reagents;Glucuronides;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents, Glucuronides, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 114127-73-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 516.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 2.82±0.70(Predicted)
• CAS DataBase Reference: [1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)cyclohexyl β-D-Glucopyranosiduronic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: [1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)cyclohexyl β-D-Glucopyranosiduronic Acid(114127-73-0)
• EPA Substance Registry System: [1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)cyclohexyl β-D-Glucopyranosiduronic Acid(114127-73-0)

Safety Data

• Hazardous Substances Data: 114127-73-0(Hazardous Substances Data)

Usage

Uses

(1S,2R,5S)-(+)-Menthol β-D-Glucuronide is a metabolite of D-(+)-Menthol (M218885).

Upstream product

• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 

Downstream Products

• 32449-92-6 D-glucurono-6,3-lactone 
• 6556-12-3 D-glucuronic acid 

Relevant articles and documents

Substrate Specificity of Glycyrrhizinic Acid Hydrolase

Glycyrrhizinic acid hydrolase produced by Aspergillus niger selectively hydrolyzed the 3-O-β-D-glucuronide linkage of glycyrrhizinic acid.The substrate specificity of this enzyme was investigated for synthetic glucuronides of aliphatic alcohols as well as natural glucuronide saponins.It was revealed that the glucuronide linkage with low molecular weight alcohols was not cleaved by this enzyme, while the 3-O-β-D-glucuronide linkage saponins of oleanolic acid was selectively hydrolyzed.It was also disclosed that both the 4-hydroxyl and carboxyl groups of the glucuronide moiety must be unsubstituted for hydrolysis by this enzyme.