114144-01-3Relevant academic research and scientific papers
Synthesis of 3,4-Disubstituted 3,4-Dihydro-2-pyrones via 2-(Silyloxy)pyrylium Salts: Regioselective Introduction of Substituents into 2-Pyrones
Kume, Takashi,Kojima, Toshikatsu,Iwasaki, Hideharu,Yamamoto, Yohsuke,Akiba, Kin-ya
, p. 1931 - 1935 (2007/10/02)
Silylation of 4,6-dimethyl- and 6-methyl-2-pyrone with tert-butyldimethylsilyl triflate affords the corresponding 2-(silyloxy)pyrylium triflates 2 quantitatively.Lithium diorganocuprates add regioselectively at position 4 of triflates 2 to give 4-substituted 2-(silyloxy)-4H-pyrans 4.Compounds 4 react with electrophiles at position 3 to give 3-bromo- (8), 3-(silyloxy)- (9), 3-methylene- (15), and 3-(1-hydroxybutyl)-3,4-dihydro-2-pyrones (16).
SYNTHESIS OF 3-ARYL- OR 3-ALKENYL-4,6-DIMETHYL-2-PYRONES BY SILVER ION PROMOTED REARRANGEMENT OF 4-ARYL- OR 4-ALKENYL-3-BROMO-4,6-DIMETHYL-3,4-DIHYDRO-2-PYRONES
Kume, Takashi,Iwasaki, Hideharu,Yamamoto, Yohsuke,Akiba, Kin-ya
, p. 3825 - 3828 (2007/10/02)
Debromination of 4-aryl- or 4-alkenyl-3-bromo-4,6-dimethyl-3,4-dihydro-2-pyrone (1) with AgSbF6 in dichloromethane or 1,2-dichloroethane induced rearrangement of the aryl or alkenyl group to the 3-position to afford the corresponding 3-substituted 2-pyron
REGIOSELECTIVE ADDITION OF ORGANOCUPRATES TO 2-SILOXYPYRYLIUM SALT; FACILE SYNTHESIS OF SUBSTITUTED 2-SILOXY-4H-PYRANS AND THEIR REACTIONS WITH ELECTROPHILES
Kume, Takashi,Iwasaki, Hideharu,Yamamoto, Yoshuke,Akiba, Kin-ya
, p. 6305 - 6308 (2007/10/02)
2-Siloxy-4H-pyrans (3) were prepared from 2-siloxypyrylium salt (2) by the addition of organocuprates to 4-position with good regioselectivity.The product 3 reacted with some electrophiles to give the corresponding 3,4-disubstituted 3,4-dihydro-2-pyrones(
