114144-16-0

Basic information

• Product Name: 6-IODO-2,3-DIHYDRO-1H-INDOLE
• Synonyms: 6-IODO-2,3-DIHYDRO-1H-INDOLE;1H-Indole, 2,3-dihydro-5-iodo-;5-Iodo-2,3-dihydro-1H-indole;5-iodoindoline
• CAS NO: 114144-16-0
• Molecular Formula: C₈H₈IN
• Molecular Weight: 245.06
• Mol File: 114144-16-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 289.617 ºC at 760 mmHg
• Flash Point: 128.956 ºC
• Appearance: /
• Density: 1.794 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 6-IODO-2,3-DIHYDRO-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-IODO-2,3-DIHYDRO-1H-INDOLE(114144-16-0)
• EPA Substance Registry System: 6-IODO-2,3-DIHYDRO-1H-INDOLE(114144-16-0)

Safety Data

• Hazardous Substances Data: 114144-16-0(Hazardous Substances Data)

Usage

General Description

6-Iodo-2,3-dihydro-1H-indole is an organic compound classified as a halogenated indole. The indole structure, which is made up of a benzene ring fused to a five-membered nitrogen-containing pyrrole ring, is a key component in many naturally occurring compounds. The addition of an iodine atom at the 6th carbon position makes this compound more reactive than the regular indole structure. Although its specific uses are not widely documented, iodinated indoles like 6-Iodo-2,3-dihydro-1H-indole are often used in scientific research, particularly in the field of medicinal chemistry, to synthesize other complex compounds or drugs.

InChI:InChI=1/C8H8IN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-2,5,10H,3-4H2

Upstream product

• 885697-10-9 1-(trifluoroacetyl)-5-iodo-2,3-dihydro-1H-indole 
• 61995-51-5 1-acetyl-2,3-dihydro-5-iodoindole 
• 16066-91-4 5-iodo-1H-indole 

Downstream Products

• 20780-76-1 5-iodoisatin 
• 114144-17-1 5-iodo-1H-indole-3-carbaldehyde 
• 16066-91-4 5-iodo-1H-indole 

Relevant articles and documents

SUBSTITUTED PYRIMIDINYL AND PYRIDINYL-PYRROLOPYRIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.

S1P RECEPTORS MODULATORS AND THEIR USE THEREOF

The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.

MACROLONE COMPOUNDS

A compound of formula (I) compositions comprising same, processes for their preparation and use of said compounds, particularly in the treatment of microbial infections.