114150-36-6Relevant articles and documents
Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer
Malerba, Paola,Crews, Brenda C.,Ghebreselasie, Kebreab,Daniel, Cristina K.,Jashim, Elma,Aleem, Ansari M.,Salam, Redoan A.,Marnett, Lawrence J.,Uddin, Md. Jashim
, p. 1837 - 1842 (2019/08/20)
Overexpression of cyclooxygenase-1 (COX-1) is associated with the initiation and progression of ovarian cancer, and targeted imaging of COX-1 is a promising strategy for early detection of this disease. We report the discovery of N-[(5-carboxy-X-rhodaminy
The regioselective synthesis of tepoxalin, 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-me thylpropanamide and related 1,5-diarylpyrazole anti-inflammatory agents
Murray,Wachter,Barton,Forero-Kelly
, p. 18 - 20 (2007/10/02)
Tepoxalin, a potent anti-inflammatory agent, and its analogs can be synthesized by condensing an appropriate arylhydrazine hydrochloride and a 6-aryl-4,6-dioxohexanoic acid in alcohol with a base catalyst. These diarylpyrazolylpropanoic acids can be converted to their N-methylhydroxamic acids by generating the requisite acid chloride, and allowing it to react with N-methylhydroxylamine.