114153-09-2

Basic information

• Product Name: 3,4-difluoro-2-methylaniline
• Synonyms: 3,4-difluoro-2-methylaniline;6-amino-2,3-difluortoluene;Benzenamine, 3,4-difluoro-2-methyl-
• CAS NO: 114153-09-2
• Molecular Formula: C₇H₇F₂N
• Molecular Weight: 143.1339864
• Mol File: 114153-09-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-difluoro-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-difluoro-2-methylaniline(114153-09-2)
• EPA Substance Registry System: 3,4-difluoro-2-methylaniline(114153-09-2)

Safety Data

• Hazardous Substances Data: 114153-09-2(Hazardous Substances Data)

Usage

General Description

3,4-difluoro-2-methylaniline is a chemical compound that consists of a benzene ring with an amino group and two fluorine atoms attached at different positions. It is a derivative of aniline and is commonly used in the production of pharmaceuticals, agrochemicals, and dyes. 3,4-difluoro-2-methylaniline is known for its strong aromatic odor and is considered to be toxic when ingested or inhaled in high concentrations. 3,4-difluoro-2-methylaniline is also known to be a skin and eye irritant, and it should be handled with caution and proper protective equipment. Additionally, it is important to follow safety guidelines and regulations when working with this chemical to avoid any potential health hazards.

Upstream product

• 914348-35-9 1,2-difluoro-3-methyl-4-nitrobenzene 
• 3863-11-4 3,4-difluoroaniline 
• 205756-46-3 N-pivaloyl-3,4-difluoroaniline 
• 114152-79-3 6-Bromo-3,4-difluoro-2-methylthiomethylaniline 
• 144298-08-8 3,4-Difluoro-2-methyl-N-(tert-butoxycarbonyl)aniline 
• 64695-79-0 2-bromo-4,5-difluoro-aniline 

Downstream Products

• 206546-13-6 N-(1-methoxy)cyclopropyl-3,4-difluoro-2-methylaniline 
• 114153-10-5 N-(3,4-difluoro-2-methylphenyl)acetamide 
• 1572511-27-3 N-(3,4-difluoro-2-methylphenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide 
• 1366297-22-4 N-(3,4-difluoro-2-methylphenyl)-3-hydroxypropanamide 
• 206546-14-7 N-(1-ethoxycyclopropyl)-3,4-difluoro-2-methylaniline 
• 114152-86-2 ethyl 2-chloro-4,5-difluoro-3-methylbenzoylacetate 
• 114152-83-9 2-Chloro-4,5-difluoro-3-methylbenzoic Acid 
• 114152-82-8 2-Chloro-4,5-difluoro-3-methylbenzonitrile 
• 114152-81-7 6-Cyano-3,4-difluoro-2-methylaniline 
• 144298-18-0 Diethyl (3,4-difluoro-2-methylanilinyl)methylidenemalonate 
• 132065-79-3 6-Bromo-3,4-difluoro-2-methylaniline 

Relevant articles and documents

Ortho lithiation of N-pivaloylfluoroanilines as a useful tool for either selective methylation or benzoxazole synthesis

Lithiation of N-pivaloyl-3,4-difluoroaniline (1a) with a slight excess of 2 mole equiv of n-butyllithium followed by methylation was studied. The reaction was found to be useful for either the selective methylation of 3,4-difluoroaniline or the synthesis of benzoxazole derivatives, depending on the reaction temperature. In the reaction of N-pivaloyl-3-chloro-4-fluoroaniline (1b) and N-pivaloyl-3-fluoroaniline (1c), the reaction proceeded rather sluggishly but benzoxazole formation predominated.

A practical route to C-8 substituted fluoroquinolones

The ortho metalation of N-(tert-butoxycarbonyl)-3,4-difluoroaniline, with t-BuLi at -78°C in THF occurred regioselectively at C-2 position. The resulting lithiated species reacted with a variety of electrophiles to give 2-substituted-3,4-difluoranilines i

1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives

Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: STR1 wherein R2 is a heterocyclic group: STR2 in which RA is H, C1 -C6 alkyl or phenyl (C1 -C6) alkyl, RB is 2-ox