114153-09-2

Usage

Uses

Used in Pharmaceutical Industry:
3,4-difluoro-2-methylaniline is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3,4-difluoro-2-methylaniline is utilized as a precursor in the production of pesticides and other agrochemicals, enhancing their effectiveness in agricultural applications.
Used in Dye Industry:
3,4-difluoro-2-methylaniline is employed as a building block in the creation of dyes, where its chemical structure imparts unique color characteristics and properties to the final products.

Upstream product

• 914348-35-9 1,2-difluoro-3-methyl-4-nitrobenzene 
• 3863-11-4 3,4-difluoroaniline 
• 205756-46-3 N-pivaloyl-3,4-difluoroaniline 
• 64695-79-0 2-bromo-4,5-difluoro-aniline 
• 144298-08-8 3,4-Difluoro-2-methyl-N-(tert-butoxycarbonyl)aniline 
• 114152-79-3 6-Bromo-3,4-difluoro-2-methylthiomethylaniline 

Downstream Products

• 144298-18-0 Diethyl (3,4-difluoro-2-methylanilinyl)methylidenemalonate 
• 206546-13-6 N-(1-methoxy)cyclopropyl-3,4-difluoro-2-methylaniline 
• 114153-10-5 N-(3,4-difluoro-2-methylphenyl)acetamide 
• 1572511-27-3 N-(3,4-difluoro-2-methylphenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide 
• 1366297-22-4 N-(3,4-difluoro-2-methylphenyl)-3-hydroxypropanamide 
• 206546-14-7 N-(1-ethoxycyclopropyl)-3,4-difluoro-2-methylaniline 
• 114152-86-2 ethyl 2-chloro-4,5-difluoro-3-methylbenzoylacetate 
• 114152-83-9 2-Chloro-4,5-difluoro-3-methylbenzoic Acid 
• 114152-82-8 2-Chloro-4,5-difluoro-3-methylbenzonitrile 
• 114152-81-7 6-Cyano-3,4-difluoro-2-methylaniline 
• 132065-79-3 6-Bromo-3,4-difluoro-2-methylaniline 

Relevant academic research and scientific papers

Ortho lithiation of N-pivaloylfluoroanilines as a useful tool for either selective methylation or benzoxazole synthesis

Lithiation of N-pivaloyl-3,4-difluoroaniline (1a) with a slight excess of 2 mole equiv of n-butyllithium followed by methylation was studied. The reaction was found to be useful for either the selective methylation of 3,4-difluoroaniline or the synthesis of benzoxazole derivatives, depending on the reaction temperature. In the reaction of N-pivaloyl-3-chloro-4-fluoroaniline (1b) and N-pivaloyl-3-fluoroaniline (1c), the reaction proceeded rather sluggishly but benzoxazole formation predominated.

BENZIMIDAZOLE DERIVATIVES

The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

A practical route to C-8 substituted fluoroquinolones

The ortho metalation of N-(tert-butoxycarbonyl)-3,4-difluoroaniline, with t-BuLi at -78°C in THF occurred regioselectively at C-2 position. The resulting lithiated species reacted with a variety of electrophiles to give 2-substituted-3,4-difluoranilines i

1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives

Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: STR1 wherein R2 is 1-pyrrolidinyl which may have 1 to 2 substituents selected from the group consisting of (i) C1 -C6 alkyl, (ii) amino-(C1 -Csub

1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives

Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: STR1 wherein R2 is a heterocyclic group: STR2 in which RA is H, C1 -C6 alkyl or phenyl (C1 -C6) alkyl, RB is 2-ox

Benzoheterocyclic compounds

Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: STR1 wherein R3 is C1 -C6 alkyl and RF is C1 -C6 alkyl, and a pharmaceutically acceptable salts thereof, said compounds havi