114157-75-4

Upstream product

• 114157-77-6 trans-2-(5-methyl-2-nitrophenoxy)cyclopentanol 
• 285-67-6 Cyclopentene oxide 
• 700-38-9 2-nitro-5-methylphenol 

Downstream Products

• 114157-99-2 [(2-{(1R,2S)-2-[2-(Bis-carboxymethyl-amino)-phenoxy]-cyclopentyloxy}-4-methyl-phenyl)-carboxymethyl-amino]-acetic acid 
• 114157-83-4 cis-1-(5-methyl-2-nitrophenoxy)-2-(2-nitrophenoxy)cyclopentane 
• 114157-90-3 cis-1-(2-amino-5-methylphenoxy)-2-(2-aminophenoxy)cyclopentane 
• 114158-01-9 ({2-{(1R,2S)-2-[2-(Bis-ethoxycarbonylmethyl-amino)-5-methyl-phenoxy]-cyclopentyloxy}-4-[methoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-phenyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester 
• 114158-02-0 ({2-{(1R,2S)-2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-cyclopentyloxy}-4-[hydroxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-phenyl}-methoxycarbonylmethyl-amino)-acetic acid methyl ester 
• 114183-82-3 ({2-{(1R,2S)-2-[2-(Bis-carboxymethyl-amino)-5-methyl-phenoxy]-cyclopentyloxy}-4-[methoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-phenyl}-carboxymethyl-amino)-acetic acid 
• 109267-14-3 ({2-{(1R,2S)-2-[2-(Bis-carboxymethyl-amino)-5-methyl-phenoxy]-cyclopentyloxy}-4-[hydroxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-phenyl}-carboxymethyl-amino)-acetic acid 
• 114157-94-7 [(2-{(1R,2S)-2-[2-(Bis-methoxycarbonylmethyl-amino)-phenoxy]-cyclopentyloxy}-4-methyl-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester 
• 114157-77-6 cis-2-(5-methyl-2-nitrophenoxy)cyclopentanol 

Relevant academic research and scientific papers

Fluorescent indicator dyes for calcium working at long wavelengths

The present invention discloses a new class of calcium specific fluorescent indicator dyes having visible excitation and emission wavelengths. The new fluorescent indicator dyes combine at least one tricyclic chromophore with a tetracarboxylate parent CA2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of BAPTA to give a rhodamine-like or fluorescein-like fluorophore. Binding of calcium2+ increases the fluorescence of the new compounds by up to 40-fold. The calcium2+ dissociation constants are in the range 0.37-2.3 microM, so that the new indicators give better resolution of high [CA2+ ] levels than were previously obtainable with predecessor compounds such as quin-2 or fluo-2. The visible excitation wavelengths of the new compounds are more convenient for fluorescent microscopy and flow cytometry than the UV required by previous indicators.

Biologically Useful Chelators That Release Ca2+ upon Illumination

A series of Ca2+-selective chelators incorporating a photosensitive o-nitrobenzhydryl ether, alcohol, or ester (λmax 350-360 nm, ε ca. 5500 M-1 cm-1) were synthesized.The key step of the syntheses required the n