1141874-52-3Relevant academic research and scientific papers
Direct C(sp3)–H allylation of 2-alkylpyridines with Morita–Baylis–Hillman carbonates via a tandem nucleophilic substitution/aza-Cope rearrangement
Ning, Shulin,Wang, Shutao,Wang, Siyu,Xiang, Jinbao,Zhang, Zhuoqi,Zheng, Lianyou
supporting information, p. 2505 - 2510 (2021/10/16)
A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope rearrangement. Various alkyl substituents on 2-alkylpyridines were tolerated in the reaction to give the allylation products in 26–91% yields. The developed method provides a straightforward and operational simple strategy for the allylic functionalization of 2-alkypyridine derivatives.
Direct one-pot introduction of 2-methylpyridines to Baylis-Hillman adducts via base-mediated 3-aza-Cope rearrangement
Lee, Hyun Seung,Lee, Sangku,Kim, Se Hee,Kim, Jae Nyoung
experimental part, p. 5039 - 5042 (2011/10/09)
An efficient and regioselective introduction method of 2-methylpyridines to the secondary position of Baylis-Hillman adducts has been developed. A base treatment of 2-methylpyridinium salt of Baylis-Hillman bromide generated N-allylenamine intermediate wh
An expedient aralkylation of Baylis-Hillman adduct via the Pd-catalyzed decarboxylative protonation strategy
Kim, Jeong Mi,Kim, Se Hee,Lee, Hyun Seung,Kim, Jae Nyoung
scheme or table, p. 1734 - 1737 (2009/07/05)
An expedient protocol of aralkylation of Baylis-Hillman adducts has been developed. This method used Pd-catalyzed decarboxylative protonation strategy to the allyl ester precursor that was made from the Baylis-Hillman adduct and allyl phenylacetate.
