114198-40-2

Upstream product

• 113727-43-8 6-Chlor-5-cyano-2-pyrrolidin-1-yl-pyrimidin-4-carbonsaeure-ethylester 
• 114198-07-1 5-Cyano-6-(ethoxycarbonylmethylsulfanyl)-2-pyrrolidin-1-yl-pyrimidin-4-carbonsaeure-ethylester 
• 114198-17-3 5-Amino-2-pyrrolidin-1-yl-thieno<2,3-d>pyrimidin-4,6-dicarbonsaeure-diethylester 
• 26215-03-2 2-chlor-3,3-dicyan-acrylsaeure-ethylester 
• 103-71-9 phenyl isocyanate 
• 114198-33-3 5-Amino-2-pyrrolidin-1-yl-thieno<2,3-d>pyrimidin-4,6-dicarbonsaeure-4-propylamid-6-ethylester 

Downstream Products

• 114198-44-6 2,4-Dioxo-3-phenyl-7-pyrrolidin-1-yl-2,4-dihydro-1H-thieno<2,3-d;4,5-d'>dipyrimidin-9-carbonsaeure-propylamid 

Relevant academic research and scientific papers

Reactions of Chloropyrimidines, I.- Synthesis of Thienopyrimidines and Pyrrolopyrimidines

Ethyl 2-chloro-3,3-dicyanoacrylate (1) reacts with N,N-dialkylcyanamides 2 to give the chloropyrimidines 4a-e.Derivatives of thioglycolic acid and sarkosine react with 4 to yield the thieno- and pyrrolopyrimidines 6a-k.Acetylation of 6a,e, and g affords 7