114209-03-9Relevant academic research and scientific papers
Photochemical Reactions of Pyrimidinethiones with Alkenes
Nishio, Takehiki,Fujisawa, Masaru,Omote, Yoshimori
, p. 2523 - 2530 (2007/10/02)
Photochemical addition reactions of pyrimidinethiones and related compounds with alkenes have been examinated.Irradiation of pyrimidine-4(3H)-thiones (1a) in the presence of electron-poor alkenes gave the 4-mercaptoalkylated pyrimidines (5), whereas irradiation of (1a) in the presence of electron-rich alkenes gave 4-alkylthiopyrimidines (6).Irradiation of quinazoline-4(3H)-thiones (1c-e) and electron-poor alkenes gave 4-subtituted quinazolines (9) and (10).This ready mode of carbon-carbon bond formation provides an efficient and novel method for alkylation of pyrimidine rings.
