1142173-53-2Relevant academic research and scientific papers
Dramatic base-oriented chemoselective tandem wacker cyclizations: Synthesis of bisbenzannelated spiroketals and 2-substituted chromans
Xin, Zhijun,Zhang, Yuan,Tao, Hua,Xue, Jijun,Li, Ying
supporting information; experimental part, p. 1579 - 1584 (2011/08/06)
A Pd(II)/Cu(II)-catalyzed chemoselective tandem aerobic cyclization of phenolic olefins leads to [5,6]-bisbenzannelated spiroketals or 2-substituted chromans, wherein it was interestingly found that the presence or absence of base could be responsible for the tunable selectivity. The [5,6]- bisbenzannelated spiroketals were achieved from tandem Wacker cyclization-aroxylation in moderate yields in the absence of base, and 2-substituted chromans were formed through base-mediated Pd(II)/Cu(II)-catalyzed tandem Wacker cyclization-Michael addition in good yields. Georg Thieme Verlag Stuttgart ? New York.
