1142199-12-9

Basic information

• Product Name: (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one
• Synonyms: (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one
• CAS NO: 1142199-12-9
• Molecular Formula: C12H10ClNO3
• Molecular Weight: 251.6657
• Mol File: 1142199-12-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one(1142199-12-9)
• EPA Substance Registry System: (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one(1142199-12-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1142199-12-9(Hazardous Substances Data)

Usage

General Description

The chemical compound (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one is an isoxazolone derivative with a chloromethyl and a methoxybenzylidene group attached to the isoxazolone ring. It is also known as isoxazol-5(4H)-one and has potential applications in medicinal chemistry due to its interesting structural features. The chloromethyl group makes it a potential building block for the synthesis of other compounds, while the methoxybenzylidene group contributes to its pharmacological properties. (4E)-3-(chloromethyl)-4-(4-methoxybenzylidene)isoxazol-5(4H)-one may be of particular interest in the development of novel pharmaceuticals or as a precursor for the synthesis of biologically active molecules.

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 5470-11-1 hydroxylamine hydrochloride 

Relevant articles and documents

Synthesis of new 1,3,4-oxadiazole and benzothiazolylthioether derivatives of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-one as potential antimycobacterial agents

A new series of 4-[(substituted benzylidene)-3-[(5-(pyridine-4-yl)-1,3,4-oxadiazole-2-ylthio)-methyl]isoxazol-5(4H)-one (6a–g) and 4-(substituted benzylidene)-3-((benzo[d]thiazol-2-ylthio)methyl)isoxazol-5(4H)-one (8a–g) was synthesized. All the synthesiz

Expeditious green synthesis of 3,4-disubstituted isoxazole-5(4H)-ones catalyzed by nano-MgO

In this work, it was found that magnesium oxide nanoparticles (nano-MgO) catalyzed one-pot three-component reaction of hydroxylamine hydrochloride with aryl aldehydes (or heteroaryl aldehydes) and β-oxoesters to synthesize some biologically active isoxazole-5(4H)-one-based heterocycles. The reactions were completed using 3?mol% catalyst loading in aqueous medium at room temperature. Nano-MgO was synthesized by precipitation and hydrothermal treatment of aqueous salt solution. The structure of the nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses. The presented environmentally friendly heterocyclization offers some interesting merits, including safety, high product yield, mild conditions, low cost, minimal waste, good atom efficiency, catalyst recoverable, energy efficiency, avoidance of hazardous organic solvents, and easy workup.

2-Hydroxy-5-sulfobenzoic acid: An efficient organocatalyst for the three-component synthesis of 1-amidoalkyl-2-naphthols and 3,4-disubstituted isoxazol-5(4H)-ones

2-Hydroxy-5-sulfobenzoic acid (2-HSBA) efficiently catalyzed the one-pot three-component synthesis of a wide variety of 1-amidoalkyl-2-naphthols and 3,4-disubstituted isoxazol-5(4H)-ones. The three-component process of substituted benzaldehydes, 2-naphthol, and amides (benzamide and acetamide) or urea occur using 10 mol% of 2-HSBA as an organocatalyst under solvent-free reaction conditions (SFRCs) at 100 °C. It was also found that the best results for the preparation of 3,4-disubstituted isoxazol-5(4H)-ones were achieved using 15 mol% of 2-HSBA under aqueous conditions at room temperature. The reactions are easy to do and were completed within 3-25 min (for amidoalkyl naphthols), and 70-120 min (for 3,4-disubstituted isoxazol-5(4H)-ones), while the expected products were obtained in 82-97 % yields. The catalyst can be recovered and reused several times in the template reactions. This procedure offers the advantages of convenience, simple operational procedure, cost-effectiveness, no use of hazardous organic solvents, and the commercial availability of the catalyst.