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1142210-78-3

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1142210-78-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1142210-78-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,2,2,1 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1142210-78:
(9*1)+(8*1)+(7*4)+(6*2)+(5*2)+(4*1)+(3*0)+(2*7)+(1*8)=93
93 % 10 = 3
So 1142210-78-3 is a valid CAS Registry Number.

1142210-78-3Downstream Products

1142210-78-3Relevant articles and documents

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells

Stazi, Giulia,Battistelli, Cecilia,Piano, Valentina,Mazzone, Roberta,Marrocco, Biagina,Marchese, Sara,Louie, Sharon M.,Zwergel, Clemens,Antonini, Lorenzo,Patsilinakos, Alexandros,Ragno, Rino,Viviano, Monica,Sbardella, Gianluca,Ciogli, Alessia,Fabrizi, Giancarlo,Cirilli, Roberto,Strippoli, Raffaele,Marchetti, Alessandra,Tripodi, Marco,Nomura, Daniel K.,Mattevi, Andrea,Mai, Antonello,Valente, Sergio

, p. 722 - 735 (2019/01/04)

In aggressive tumors, alkylglyceronephosphate synthase (AGPS) controls cellular ether phospholipid utilization and metabolism to promote cancer cell proliferation and motility. SAR studies on the first-in-class AGPS inhibitor 1, discovered by our group, led to the 2,6-difluoro analog 2i which showed higher binding affinity than 1 in vitro. In 231MFP cancer cells, 2i reduced ether lipids levels and cell migration rate. When tested in PC-3 and MDA-MB-231 cancer cells, 2i specifically impaired epithelial to mesenchymal transition (EMT) by modulating E-cadherin, Snail and MMP2 expression levels. Moreover, the combination of siRNAs against AGPS and 2i provided no additive effect, confirming that the modulation of 2i on EMT specifically relies on AGPS inhibition. Finally, this compound also affected cancer cell proliferation especially in MDA-MB-231 cells expressing higher AGPS level, whereas it provided negligible effects on MeT5A, a non-tumorigenic cell line, thus showing cancer specificity.

Rhodium(I)-catalyzed enantioselective hydrogenation of substituted acrylic acids with sterically similar β,β-diaryls

Li, Yang,Dong, Kaiwu,Wang, Zheng,Ding, Kuiling

, p. 6748 - 6752 (2013/07/26)

Distinct differentiation: β,β-Disubstituted acrylic acids with sterically similar geminal diaryl groups can be hydrogenated with excellent enantioselectivities in the presence of a RhI complex formed in situ with two-component ligands, a chiral secondary phosphine oxide (SPO) and an achiral phosphine (Ph3P). The sense of asymmetric induction was found to be controlled by the substrate configuration, thus allowing access to both enantiomers of the product with the same catalyst. Copyright

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