114223-12-0

Basic information

• Product Name: 3-(2-methylphenoxy)-3-oxo-propanoic acid
• Synonyms: 3-(2-methylphenoxy)-3-oxo-propanoic acid
• CAS NO: 114223-12-0
• Molecular Weight: 194.187
• Mol File: 114223-12-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(2-methylphenoxy)-3-oxo-propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methylphenoxy)-3-oxo-propanoic acid(114223-12-0)
• EPA Substance Registry System: 3-(2-methylphenoxy)-3-oxo-propanoic acid(114223-12-0)

Safety Data

• Hazardous Substances Data: 114223-12-0(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 95-48-7 ortho-cresol 

Downstream Products

• 767289-07-6 8-methyl-4-tosyloxy[1]benzopyran-2-one 
• 1577989-11-7 (R)-o-tolyl-2-(6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate 
• 83-40-9 3-methylsalicylic acid 

Relevant articles and documents

Regioselective Synthesis of 4,5-Dihydro-6H-oxepino[3,2-c]chromene-2,6(3H)-diones through Palladium-Catalyzed Intramolecular Alkoxycarbonylation of 3-Allyl-4-hydroxycoumarins

Seven-membered ring lactones fused to coumarin scaffolds were obtained via a palladium-catalyzed regioselective intramolecular alkoxycarbonylation under a CO atmosphere. Cyclocarbonylation of 3-allyl-4-hydroxycoumarin derivatives was accessed in the absen

Synthesis and antiproliferative activity of hybrid thiosemicarbazone derivatives bearing coumarin and d-galactose moieties with EGFR inhibitory activity and molecular docking study

A series of substituted N-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)thiosemicarbazones 5a–5j of substituted 3-acetylcoumarins were synthesized with yields of 45–68%. All synthesized thiosemicarbazones were evaluated for cytotoxic activity against several cancer cell lines, such as human breast adenocarcinoma cells MCF7, human liver cancer cells HepG2, human cervical cancer cells HeLa, human melanoma cancer cells SK-Mel-2, and human lung cancer cells LU-1 by using the standard MTT assay. The IC50 values for these cancer cell lines were 1.28–11.81 μM (for MCF-7), 1.53–22.12 μM (for HepG2), 1.43–48.16 μM (for HeLa), 1.82–14.62 μM (for SK-Mel-2), and 1.74–14.62 μM (for LU-1). Most of the compounds were noncytotoxic against human WI-38 normal cell line (IC50 > 16.9 μM). The antiproliferative mechanisms were studied via EGFR inhibition and molecular docking. Docking studies revealed that there are strong interactions between a typical compound with the receptor of the EGFR tyrosine kinase domain with Erlotinib. [Figure not available: see fulltext.]

Clean and convenient one-pot synthesis of 4-hydroxycoumarin and 4-hydroxy-2-quinolinone derivatives

A simple, efficient, and environmentally friendly procedure has been developed for the reaction of Meldrum's acid with phenol, substituted phenols, aniline, or substituted anilines with Eaton's reagent (phosphoric anhydride+methylsulfonic acid) as cyclization reagent. 4-Hydroxycoumarins and 4-hydroxy-2-quinolinones were synthesized in moderate yields by carrying out the reaction in solvent-free, convenient, and clean one-pot preparation.