1142292-47-4Relevant academic research and scientific papers
BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF
-
Page/Page column 18-19, (2010/07/08)
The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant
RETINOID PRODRUG COMPOUND
-
Page/Page column 19-20, (2010/08/18)
A compound represented by the following general formula (I) : [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents -NH-CO-, -CO-NH-, -N(COR6)-CO-, -CO-N(COR7)- (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents -Y-CH(R12)-COOH, -CHO, -CH-CH-COOH, or -COOR13 (Y represents a single bond, -CH2-, -CH(OH)-, -CO-, -CO-NH-, or -CO-NH-CH2-CO-NH-, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, -CH(R14)-COOH (R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), -[CH2CH2-O]n-CH2-CH2-OH, CH2-O-[CH2CH2O]m-CH2-OH, or -[CH(CH3)-CO-O]p-CH(CH3)-COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
RETINOID PRODRUG COMPOUND
-
Page/Page column 17, (2010/12/29)
A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(COR6)—CO—, —CO—N(COR7)— (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents —Y—CH(R12)—COOH, —CHO, —CH═CH—COOH, or —COOR13 (Y represents a single bond, —CH2—, —CH(OH)—, —CO—, —CO—NH—, or —CO—NH—CH2—CO—NH—, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, —CH(R14)—COOH(R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), —[CH2CH2—O]n—CH2—CH2—OH, —CH2—O—[CH2CH2—O]m—CH2—OH, or —[CH(CH3)—CO—O]p—CH(CH3)—COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
