1142408-76-1

Basic information

• Product Name: 3-(4-hydroxyphenyl)-1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-one
• Synonyms: 3-(4-hydroxyphenyl)-1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-one
• CAS NO: 1142408-76-1
• Molecular Weight: 257.252
• Mol File: 1142408-76-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-hydroxyphenyl)-1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-hydroxyphenyl)-1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-one(1142408-76-1)
• EPA Substance Registry System: 3-(4-hydroxyphenyl)-1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-one(1142408-76-1)

Safety Data

• Hazardous Substances Data: 1142408-76-1(Hazardous Substances Data)

Upstream product

• 1142408-69-2 3-(4-hydroxyphenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione 

Downstream Products

• 598-50-5 N-Methylurea 

Relevant articles and documents

Synthesis of 6-azapurines by transformation of toxoflavins and reumycins (7-azapteridines) and their cytotoxicities

This paper describes a reliable and facile synthesis of 6-azapurines, 1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-ones and 5-methyl-5H-imidazo[4,5-e][1,2,4]triazin-6(7H)-ones, by treatment of toxoflavins and reumycins with 10% aqueous or ethanolic sodium hydroxide at 5-70°C or reflux, followed by decarboxylation and oxidation by air along with a benzilic acid type rearrangement. Furthermore, heating the produced 6-azapurines in 10% ethanolic sodium hydroxide afforded the corresponding 1-methyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazines with 1-methylurea. The antitumour activities of the 6-azapurines against CCRF-HSB-2 (human T-cell acute lymphoblastoid leukemia) and KB (human oral epidermoid carcinoma) cell lines were also investigated in vitro and some of the compounds showed prospective antitumour activities.