1142408-77-2

Upstream product

• 878419-68-2 1,6-dimethyl-3-(p-tolyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione 

Downstream Products

• 1142408-80-7 1-methyl-5,6-dioxo-3-p-tolyl-1,4,5,6-tetrahydro-1,2,4-triazine 
• 598-50-5 N-Methylurea 

Relevant academic research and scientific papers

Synthesis of 6-azapurines by transformation of toxoflavins and reumycins (7-azapteridines) and their cytotoxicities

This paper describes a reliable and facile synthesis of 6-azapurines, 1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-ones and 5-methyl-5H-imidazo[4,5-e][1,2,4]triazin-6(7H)-ones, by treatment of toxoflavins and reumycins with 10% aqueous or ethanolic sodium hydroxide at 5-70°C or reflux, followed by decarboxylation and oxidation by air along with a benzilic acid type rearrangement. Furthermore, heating the produced 6-azapurines in 10% ethanolic sodium hydroxide afforded the corresponding 1-methyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazines with 1-methylurea. The antitumour activities of the 6-azapurines against CCRF-HSB-2 (human T-cell acute lymphoblastoid leukemia) and KB (human oral epidermoid carcinoma) cell lines were also investigated in vitro and some of the compounds showed prospective antitumour activities.

The facile synthesis of 6-azapurines by transformation of toxoflavins (7-azapteridines)

This paper describes a reliable and facile synthesis of 6-azapurines (1,5-dimethyl-1H imidazo[4,5-e][1,2,4]triazin-6(5H)-ones) by treatment of toxoflavins (7-azapteridines) with 10% aqueous sodium hydroxide at 5-25 °C along with a benzilic acid type rearr