114258-52-5

Upstream product

• 20999-32-0 4-chlorobutyl 4-methylbenzenesulfonate 
• 90-02-8 salicylaldehyde 
• 6940-78-9 4-chlorobutyl bromide 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 81821-83-2 (Z)-2-Benzo[d]isoxazol-3-yl-3-[2-(4-chloro-butoxy)-phenyl]-acrylonitrile 
• 103076-68-2 2-(4-chlorobutoxy)benzaldehyde ethylene acetal 
• 1002414-13-2 2-[4-(4-methyl-piperazin-1-yl)-butoxy]-benzaldehyde 
• 103073-26-3 2-{2-[4-(4-Phenyl-piperazin-1-yl)-butoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide 
• 103076-38-6 2-[2-(4-Chloro-butoxy)-phenyl]-thiazolidine-3-carbothioic acid methylamide 

Relevant academic research and scientific papers

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor. Structure-activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H4 receptor.

Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists

The invention features methods of using pharmaceutically-active 2- or 3-aryl substituted imidazopyridines and derivatives.