114278-00-1

Basic information

• Product Name: 4-Piperidinecarboxylic acid, 4-phenyl-1-(4-phenylbutyl)-, ethyl ester
• CAS NO: 114278-00-1
• Molecular Formula: C24H31NO2
• Molecular Weight: 365.516
• Mol File: 114278-00-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Piperidinecarboxylic acid, 4-phenyl-1-(4-phenylbutyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinecarboxylic acid, 4-phenyl-1-(4-phenylbutyl)-, ethyl ester(114278-00-1)
• EPA Substance Registry System: 4-Piperidinecarboxylic acid, 4-phenyl-1-(4-phenylbutyl)-, ethyl ester(114278-00-1)

Safety Data

• Hazardous Substances Data: 114278-00-1(Hazardous Substances Data)

Upstream product

• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 64-17-5 ethanol 
• 772299-15-7 4-Cyano-1-(4-phenylbutyl)-4-phenylpiperidin 
• 13633-25-5 1-Bromo-4-phenylbutane 
• 24465-45-0 ethyl 4-phenyl-4-piperidinecarboxylate hydrochloride 

Relevant articles and documents

Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine

P-Glycoprotein (P-gp) is an efflux transporter which is up-regulated at the blood-brain barrier in both morphine- and oxycodone-tolerant rats. Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-gp, suggesting that up-regulation of P-gp may contribute to the development of central tolerance to opioids. The studies herein focus on the development of SAR for P-gp substrate activity in the meperidine series of compounds, and show that a meperidine analog of greater potency, N-phenylbutyl-N-normeperidine, has low activity as a P-gp substrate and has the potential to be utilized as a tool to study the contribution of P-gp to the development of central tolerance to opioids.