1142947-80-5

Basic information

• Product Name: 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]aMino]-
• Synonyms: 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]aMino]-;3,7-Dihydro-2-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one
• CAS NO: 1142947-80-5
• Molecular Formula: C₁₇H₂₀N₆O
• Molecular Weight: 324.3803
• Mol File: 1142947-80-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]aMino]-(1142947-80-5)
• EPA Substance Registry System: 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]aMino]-(1142947-80-5)

Safety Data

• Hazardous Substances Data: 1142947-80-5(Hazardous Substances Data)

Usage

Description

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]amino]is a chemical compound that serves as a reactant in the synthesis of pyrrolopyrimidine compounds. These compounds are known as Janus kinase inhibitors, which are a class of enzymes involved in cell signaling pathways. The inhibition of these enzymes has potential applications in the treatment of various diseases, including cancer.

Uses

Used in Pharmaceutical Industry:
4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-2-[[3-(4-Methyl-1-piperazinyl)phenyl]amino]is used as a reactant for the preparation of pyrrolopyrimidine compounds, which are Janus kinase inhibitors. These inhibitors have potential applications in the treatment of cancer due to their ability to target and regulate the activity of Janus kinase enzymes, which play a crucial role in cell signaling pathways involved in the development and progression of cancer.

Upstream product

• 1142947-79-2 6-amino-5-(2,2-diethoxy-ethyl)-2-[3-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-ol 

Downstream Products

• 1142947-81-6 (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine 

Relevant articles and documents

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS

Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.