114306-55-7Relevant academic research and scientific papers
Synthesis of N,N′-diarylalkanediamides and their antimycobacterial and antialgal activity
Kubicova, Lenka,Waisser, Karel,Kunes, Jiri,Kralova, Katarina,Odlerova, Zelmira,Slosarek, Milan,Janota, Jiri,Svoboda, Zbynek
, p. 714 - 726 (2007/10/03)
A set of N,N′-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N′-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacteri-ally active substances were found only in the series of N,N′-diarylethanediamides and N,N′-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antial-gal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.
KINETICS OF THE ACYLATION OF MONOSUBSTITUTED AROMATIC AMINES BY ACID CHLORIDES
Khardin, A. P.,Novakov, I. A.,Radchenko, S. S.,Brel', N. A.,Chegolya, A. S.,et al.
, p. 1492 - 1495 (2007/10/02)
The kinetics of the acylation of p-toluidine and 1-(4-aminophenyl)adamantane by acid chlorides were investigated.It was established that adamantanecarbonyl chlorides have lower reactivity than cyclohexanecarbonyl chlorides and aliphatic acid chlorides.
