114341-88-7

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(2-BROMOPROPANOYL)-4,4-DIMETHYL-1,3-OXAZOLIDIN-2-ONE is used as a reagent for the synthesis of pharmaceuticals and other organic molecules. Its unique structure allows it to be a valuable intermediate in the creation of new drug candidates.
Used in Peptide Synthesis:
In the field of biochemistry, 3-(2-BROMOPROPANOYL)-4,4-DIMETHYL-1,3-OXAZOLIDIN-2-ONE is used as a coupling agent in peptide synthesis. This role is crucial for the formation of peptide bonds, which are the backbone of proteins.
Used in Heterocyclic Compound Construction:
3-(2-BROMOPROPANOYL)-4,4-DIMETHYL-1,3-OXAZOLIDIN-2-ONE is also used as a building block in the construction of heterocyclic compounds. These compounds are important in the development of new materials and pharmaceuticals due to their diverse chemical properties and potential applications.
Used in Chemical Research:
In the broader field of chemical research, 3-(2-BROMOPROPANOYL)-4,4-DIMETHYL-1,3-OXAZOLIDIN-2-ONE is utilized for its potential to contribute to the understanding of chemical reactions and the development of new synthetic methods.
It is important to handle 3-(2-BROMOPROPANOYL)-4,4-DIMETHYL-1,3-OXAZOLIDIN-2-ONE with care and to follow proper safety precautions due to its potential hazards, ensuring that its benefits can be realized while minimizing any risks associated with its use.

InChI:InChI=1/C8H12BrNO3/c1-5(9)6(11)10-7(12)13-4-8(10,2)3/h5H,4H2,1-3H3

Upstream product

• 26654-39-7 4,4-dimethyl-1,3-oxazolidin-2-one 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 114418-63-2 (3S,4R)-3-<(R)-1-(t-Butyldimethylsilyloxy)ethyl>-4-<(S)-1-(4,4-dimethyl-2-oxazolidone-3-carbonyl)ethyl>-2-azetidinone 
• 114341-89-8 (3S,4R)-3-<(R)-1-(t-Butyldimethylsilyloxy)ethyl>-4-<(R)-1-(4,4-dimethyl-2-oxazolidone-3-carbonyl)ethyl>-2-azetidinone 
• 116616-40-1 4,4-Dimethyl-3-((2R^*,3S^*)-3-hydroxy-2-methyl-3-phenylpropionyl)-2-oxazolidone 
• 116616-40-1 4,4-Dimethyl-3-((2R^*,3R^*)-3-hydroxy-2-methyl-3-phenylpropionyl)-2-oxazolidone 
• 150968-18-6 4,4-dimethyl-3-propionyloxazolidin-2-one 

Relevant academic research and scientific papers

A synthetic penem antibiotics of hand natural auxiliary base preparation method

The present invention relates to the field of medicinal chemistry for the preparation of the product, in particular to a synthetic penem antibiotics of hand natural auxiliary base preparation method. The synthetic penem antibiotics of hand natural auxilia

2-(2-substituted pyrrolidin-4-yl) thio-carbapenem derivatives

The present invention relates to 2-(2-substituted pyrrolidin-4-yl)-thio-carbapenem derivatives and pharmaceutically acceptable salts thereof, to a process for preparing the derivatives, an intermediate compound for preparing the derivatives, an antibacterial composition containing the derivatives, and use of the derivatives as an antibacterial agent.

Heterocyclic compounds and their production

A compound of the formula: STR1 wherein R1, R2, R3 and R4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R1 and R2 may be combined together to f

Highly stereocontrolled synthesis of the 1β-methylcarbapenem key intermediate by the Reformatsky reaction of 3-(2-bromopropionyl)-2-oxazolidone derivatives with a 4-acetoxy-2-azetidinone

The key synthetic intermediate (4) of 1β-methylcarbapenems (1~3) was efficiently synthesized by employing highly stereocontrolled Reformatsky reaction (C4-alkylation) of 3-(2-bromopropionyl)-2-oxazolidone derivatives (6) with (3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidino ne (5) in the presence of zinc dust followed by removal of 2-oxazolidone moieties. The best diastereoselectivity (β:α = 95:5) could be realized by uses of sterically crowded achiral 2-oxazolidone derivatives such as 4,4-dimethyl-, 4,4,5,5-tetramethyl, and 4,4-dibutyl-5,5-pentamethylene-2-oxazolidone and higher reaction temperatures (refluxing tetrahydrofran). The remarkable diastereoselectivities observed for the Reformatsky reactions could be explained by means of the weakly chelating transition state models.