114343-31-6

Basic information

• Product Name: O-(N-morpholinocarbonyl)-3-phenyllactic acid
• Synonyms: O-(N-morpholinocarbonyl)-3-phenyllactic acid
• CAS NO: 114343-31-6
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.29
• Mol File: 114343-31-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 457.6°Cat760mmHg
• Flash Point: 230.6°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 3.62E-09mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: O-(N-morpholinocarbonyl)-3-phenyllactic acid(CAS DataBase Reference)
• NIST Chemistry Reference: O-(N-morpholinocarbonyl)-3-phenyllactic acid(114343-31-6)
• EPA Substance Registry System: O-(N-morpholinocarbonyl)-3-phenyllactic acid(114343-31-6)

Safety Data

• Hazardous Substances Data: 114343-31-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H17NO5/c16-13(17)12(10-11-4-2-1-3-5-11)20-14(18)15-6-8-19-9-7-15/h1-5,12H,6-10H2,(H,16,17)/t12-/m0/s1

Upstream product

• 13673-95-5 (S)-methyl 2-hydroxy-3-phenylpropanoate 
• 114359-57-8 methyl 2(S)-<(4-morpholinylcarbonyl)oxy>-3-phenylpropionate 

Downstream Products

• 114457-15-7 Morpholine-4-carboxylic acid (S)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl ester 

Relevant articles and documents

N-HETEROCYCLIC ALCOHOL DERIVATIVES

Compounds of the formula STR1 wherein R 1 is an N-heterocyclic group as defined herein, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

Peptidyl difluorodiol renin inhibitors

A renin inhibiting compound of the formula: wherein A is a functional group; W is (1)-C(O)-,(2)-CH(OH)-or(3)-N(R?)-wherein R? is hydrogen or loweralkyl; U is (1)-C(O)-,(2)-CH?-or(3)-N(R?)-wherein R? is hydrogen or lower alkyl, with the proviso that when W is-CH(OH)-then U is-CH?-and with the proviso that U is-C(O)-or-CH?-when W is-N(R?)-; V is (1)-CH-,(2)-C(OH)-or(3)-C(halogen)-with the proviso that v is-CH--when U is-N(R?)-; Q is-CH(R?)-or-C(=CHR1a)-wherein R? is (1) loweralkyl,(2) cycloalkylalkyl,(3) arylalkyl,(4) (heterocyclic) alkyl,(5) 1-benzyloxyethyl,(6) phenoxy,(7) thiophenoxy or(8) anilino, provided that B is-CH?-or-CH(OH)-or A is hydrogen when R? is phenoxy, thiophenoxy or anilino and R1a is aryl or heterocyclic; R? is a functional group; R? is (1) loweralkyl,(2) cycloalkylmethyl or(3) benzyl; R? is-CH(OH)-or-C(O)-; R? is-CH(OH)-or-C(O)-; and Z is (1) lower alkyl,(2) aryl,(3) arylalkyl,(4) cycloalkyl,(5) cycloalkylalkyl,(6) heterocyclic or(7) (heterocyclic)alkyl; or a pharmaceutically acceptable salt, ester or prodrug thereof.

Novel amino acid derivatives possessing renin-inhibitory activities

An amino acid derivative of the general formula: wherein, R1? is a lower alkyl group and R11 is (wherein R111 is a lower alkyl group and n is an integer of 1 to 5) or a lower alkyl group which may be substituted by hydroxy group or methoxyethoxymethoxy group, or R1? and R11 are combinedly together with the adjacent nitrogen atom; R12 is a hydrogen atom, CnH2n+ 1-O-CO-(n is as defined above) or R13 is a lower alkyl group which may be substituted by substituent(s) selected from HOOC-(H?C)n-O-, R12-NH-(n and R12 are as defined above) and pyridyl group; X is-CH?-,-O-or-NH-and Y is-O-or-NH-; wherein (wherein Z is-O-,-S-,-S(O)-,-S(O)?-,-CH?-,-CH(OH)-,---,-NH-or and a and b are independently an integer of 1 to 4 and the total of a and b is not more than 5) ; R2 is an aralkyl group which may be substituted by lower alkyl group(s); R3 is a hydrogen atom or a lower alkyl group; R? is a lower alkyl group; and A is hydroxy group and B is a hydrogen atom, or A and B are carbonyl group combinedly together with the adjacent carbon atom, a pharmaceutically acceptable acid addition salt or an ester thereof is described. The compounds of the invention possess inhibitory activities against renin and are useful as an antihypertensive agent.