114361-77-2Relevant academic research and scientific papers
Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Part LX - Synthesis of Thiazolotriazinoindoles
Dahiya, Rajinder,Narayan, Sat,Bindal, Varinder,Kumar, Vinod,Handa, R. N.,Pujari, H. K.
, p. 535 - 538 (2007/10/02)
5-Substituted-isatins (IIa,b), obtained by the reaction of appropriate anilines (Ia,b) with chloral hydrate and hydroxylamine, on condensation with thiosemicarbazide, give isatinthiosemicarbazones (IIIa,b).Compounds IIIa,b on reaction with α-halogenoketones furnish the uncyclized compounds (IVa,b) which on cyclization with phosphoryl chloride afford 1,7-disubstituted thiazolotriazinoindoles (Va,b).Compounds IIIa,b on condensation with 1,2-dibromoethane give 7-substituted 2,3-dihydrothiazolotriazinoindoles (VIa,b).VIa is also obtained from IIIa via VIIa.The structures IV-VI have been established by IR, PMR and mass spectral data.
