114362-19-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyrimidinamine, 2-(1-methylethyl)(9CI) is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds. Its unique structure allows it to be a key component in the creation of drugs targeting a wide range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Pyrimidinamine, 2-(1-methylethyl)(9CI) is utilized as an intermediate in the synthesis of agrochemicals, playing a crucial role in the development of products designed to enhance crop protection and improve agricultural yields.
Used in Research Applications:
4-Pyrimidinamine, 2-(1-methylethyl)(9CI) also serves as a valuable building block in research settings, where it is employed in the design and synthesis of new compounds for scientific exploration and potential applications across diverse fields.

Upstream product

• 61349-72-2 2-isopropyl-pyrimidine 

Relevant academic research and scientific papers

11B-HSD1 inhibitors for the treatment of diabetes

Compounds of the formula (I): as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.

On the Chichibabin Amination of Pyrimidine and N-Alkylpyrimidinium Salts Using Liquid Ammonia/Potassium Permanganate

Treatment of the 2-R-pyrimidines (1, R = methyl, ethyl, i-propyl and t-butyl) with potassium amide/liquid ammonia/potassium permanganate leads to amination at C-4(6).The yields of the 4(6)-amino compounds 3 increase in the order 2-methyl (10percent), 2-ethyl (30percent), 2-i-propyl (45percent) and 2-t-butyl (60percent).Treatment of the 2-R-N-methylpyrimidinium salts (4, R = hydrogen, methyl) with liquid ammonia/potassium permanganate leads to a regiospecific imination at C-6, the corresponding 2-R-1,6-dihydro-6-imino-1-methylpyrimidines 6 being obtained in 80-85percent yield.It is proved by 15N-labelling that no ring opening is involved in these imination reactions.Treatment of the imino compounds with base leads to the corresponding 2-R-6-methylaminopyrimidines 8, involving, as proved by 15N-labelling, an ANRORC-mechanism. 2-t-Butyl-1-ethylpyrimidinium tetrafluoroborate (9b) when treated with liquid ammonia/potassium permanganate undergoes N-deethylation, 2-t-butylpyrimidine being exclusively formed.