114364-72-6

Basic information

• Product Name: Benzenesulfonamide, N-[2-(1H-indol-1-yl)ethyl]-4-methyl-
• CAS NO: 114364-72-6
• Molecular Formula: C17H18N2O2S
• Molecular Weight: 314.408
• Mol File: 114364-72-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-(1H-indol-1-yl)ethyl]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-(1H-indol-1-yl)ethyl]-4-methyl-(114364-72-6)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-(1H-indol-1-yl)ethyl]-4-methyl-(114364-72-6)

Safety Data

• Hazardous Substances Data: 114364-72-6(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 

Relevant articles and documents

Cu(I)-Catalyzed Intramolecular Tandem Cyclization of N-Indole-Tethered Cyclopropenes: Synthesis of Functionalized Hydrogenated Diazabenzo[ a]cyclopenta[ cd]azulene Derivatives

A Cu(I)-catalyzed [3 + 2] intramolecular cycloaddition reaction of N-indole-tethered cyclopropenes is presented in this paper. This reaction starts from the formation of ?-allyl cationic intermediate or its resonance-stabilized metal carbenoid intermediate upon activation of cyclopropene with Cu(I) catalyst and a Friedel-Crafts-type cyclization to give functionalized hydrogenated diazabenzo[a]cyclopenta[cd]azulenes in good to excellent yields along with moderate to good dr values. The asymmetric variant of this cycloaddition reaction can be realized, giving the desired products with moderate ee values.

Reactions with Aziridines, 52. - Branched-Chain Tryptamine Compounds from Indolyllithium and Activated Aziridines

Reaction of indolyllithium 1 with activated aziridines 2 in toluene provides the tryptamines 3 or 4 in good yields. - Key Words: Nucleophilic ring opening / Regioselectivity / Ambident nucleophiles / Aziridines / Tryptamine