114380-40-4

Upstream product

• 458-37-7 curcumin 
• 121-33-5 vanillin 
• 458-37-7 curcumin 
• 98885-93-9 curcumin 
• 147556-16-9 curcumin 
• 123-54-6 acetylacetone 
• 814919-70-5 (1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one 

Downstream Products

• 1246537-26-7 C₂₃H₂₃NO₅ 
• 1246537-13-2 C₂₃H₂₃NO₅ 
• 1246537-14-3 C₂₅H₂₇NO₅ 
• 1246537-09-6 C₂₆H₂₉NO₅ 
• 1246537-07-4 C₂₆H₂₉NO₅ 
• 1246537-10-9 C₃₁H₃₉NO₅ 
• 1246537-15-4 C₂₃H₂₁NO₆ 
• 1246537-17-6 C₂₃H₂₁NO₆ 
• 1246537-18-7 C₂₅H₂₃NO₇ 
• 1246537-11-0 C₂₆H₂₇NO₅ 
• 1246537-25-6 C₂₆H₂₇NO₅ 
• 1246537-12-1 C₃₁H₃₅NO₅ 
• 1118765-46-0 (E,E)-3,5-bis(3,4-dimethoxystyryl)isoxazole 
• 1246537-19-8 C₂₂H₂₁NO₅ 

Relevant academic research and scientific papers

Effect of solvent on the photophysical properties of isoxazole derivative of curcumin: A combined spectroscopic and theoretical study

The present work aims to decipher the photophysics of a β-diketo modified curcumin analog named isoxazole derivative of curcumin (IOC). IOC itself happens to be a potential drug molecule possessing numerous biological applications such as; anti-cancer, an

Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents

Curcuminoids were isolated from Curcuma longa and their pyrazole and isoxazole analogues were synthesized and evaluated for antioxidant, COX-1/COX-2 inhibitory and anti-inflammatory activities. The designed analogues significantly enhance COX-2/COX-1 selectivity and possess significant anti-inflammatory activity in carrageenan induced rat paw edema assay. Pyrazole, isoxazole analogues of curcumin (4 and 7) exhibited higher antioxidant activity than trolox. Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX and thereby helps to design novel potent inhibitors.

In-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin

In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder molecule from the spice turmeric and structures

Perturbations in the photophysical properties of isoxazole derivative of curcumin up on interaction with different anionic, cationic and non-ionic surfactants

Surfactants are organized assemblies that are often used as models for biomembranes and they can also act as solubilizing agents for various hydrophobic drug molecules. Isoxazole derivative of curcumin (IOC) is a potential drug molecule whose biological e

The inhibitory potency of isoxazole-curcumin analogue for the management of breast cancer: A comparative in vitro and molecular modeling investigation

Curcumin, a potent phytochemical derived from the spice element turmeric, has been identified as a herbal remedy decades ago and has displayed promise in the field of medicinal chemistry. However, multiple traits associated with curcumin, such as poor bio

Synergistic antifungal effects of curcumin derivatives as fungal biofilm inhibitors with fluconazole

Lack of novel antifungal agents and severe drug resistance has led to high incidence and associated mortality of invasive fungal infections. To tackle the challenges, novel antifungal agents with anti-resistant potency are highly desirable. Thus, derivati

The inhibitory role of curcumin derivatives on AMPA receptor subunits and their effect on the gating biophysical properties

Curcumin is a natural polyphenol that has a broad spectrum of therapeutic characters, including neuroprotective actions against various neurological diseases. However, the molecular mechanism behind its neuroprotective properties remains obscure. The curr

New histone deacetylase inhibitors and anticancer agents from Curcuma longa

The aims of this study were to explore histone deacetylase inhibitory and antioxidant activities of curcuminoids as well as derivatives of curcumin. Curcumin (6), demethoxycurcumin (7), dihydrocurcumin (8), bisdemethoxycurcumin (9), and hydroxycurcumin (1

Screening of curcumin-derived isoxazole, pyrazoles, and pyrimidines for their anti-inflammatory, antinociceptive, and cyclooxygenase-2 inhibition

Curcumin has shown pharmacological properties against different phenotypes of various disease models. Different synthetic routes have been employed to develop its numerous derivatives for diverse and improved therapeutic roles. In this study, we have synt

Synthesis of curcuminoids and evaluation of their cytotoxic and antioxidant properties

Curcumin (1) and ten derivatives (2-11) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that 7 has potent activity; even stronger than curcumin, α-tocopherol, and quercetin.