114396-70-2

Basic information

• Product Name: (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid
• Synonyms: (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid
• CAS NO: 114396-70-2
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.2512
• Mol File: 114396-70-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 123-126 °C
• Boiling Point: 483.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.313±0.06 g/cm3(Predicted)
• PKA: 3.70±0.11(Predicted)
• CAS DataBase Reference: (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid(114396-70-2)
• EPA Substance Registry System: (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid(114396-70-2)

Safety Data

• Hazardous Substances Data: 114396-70-2(Hazardous Substances Data)

Usage

General Description

(S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid is a chemical compound with a complex structure that includes a benzyloxycarbonyl-protected amino group and a hydroxy group attached to a methyl group. The compound is a derivative of the amino acid serine, with the benzyloxycarbonyl group protecting the amino group from chemical reactions. (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid may have potential applications in medicinal chemistry and drug development, as the modification of amino acids can lead to the creation of new compounds with desirable biological properties. However, further research and testing would be needed to fully understand the potential uses and properties of (S)-2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoic acid.

Upstream product

• 357274-59-0 (S)-methyl 2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 3398-40-1 (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid 
• 501-53-1 benzyl chloroformate 
• 3005-66-1 diethyl 2-benzyloxycarbonylaminomalonate 
• 212776-36-8 diethyl 2-(benzyloxycarbonylamino)-2-methylmalonate 
• 212776-40-4 (R)-2-Benzyloxycarbonylamino-2-methyl-malonic acid monoethyl ester 
• 114396-62-2 (S)-α-methylserine hydrochloride 

Downstream Products

• 357274-59-0 (S)-methyl 2-(benzyloxycarbonylamino)-3-hydroxy-2-methylpropanoate 
• 1163132-29-3 C₂₂H₂₆N₂O₆ 
• 1163132-20-4 C₂₂H₂₆N₂O₆ 
• 114396-72-4 Z-α-MeSer(OtBu)-OBzl 
• 114396-71-3 Z-α-MeSer(OH)-OBzl 

Relevant articles and documents

Total synthesis and structure elucidation of JBIR-39: A linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues

The total synthesis and stereochemical structural elucidation of JBIR-39, containing four nonproteinogenic piperazic acid (Piz) residues, is reported. The synthesis includes Sc(OTf)3-catalyzed acylation of a Piz(γ-OTBS) derivative with piperazi

ORALLY AVAILABLE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS AND ANTAGONISTS

The present invention relates to S1P analogs that have activity as S1Preceptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and; R2 is selected from the group consisting of H, C1-C4 alkyl, (C1-C4 alkyl)OH and (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is a phosphonate ester or a phosphate ester or a pharmaceutically acceptable salt or tautomer thereof.

New enantiodivergent procedure for the syntheses of chiral α- substituted serines from α-alkyl-α-aminomalonates utilizing enzymatic hydrolysis

Porcine liver esterase (PLE)- or rabbit liver esterase (RLE)-catalyzed hydrolysis of the pro-S ester group of diethyl α-alkyl-α- (benzyloxycarbonylamino)malonates 2a-c afforded (R)-ethyl α-alkyl-α- (benzyloxycarbonylamino)malonates 3a-c each in excellent enantiomeric excess. Enantiodivergent reductions of these acid esters 3a-c readily furnished both the corresponding enantiomeric α-substituted serines (R)- and (S)-5a-c.