1144072-40-1 Usage
Uses
Used in Pharmaceutical Industry:
Urea, N-[4-(4-methyl-1-piperazinyl)phenyl]-N'-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]is used as a potential drug candidate for the development of new medications, particularly in the area of kinase inhibitor therapy. Its unique molecular structure, including the pyrazolo-pyrimidin-yl group, positions it as a candidate for targeting specific kinases involved in various diseases.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Urea, N-[4-(4-methyl-1-piperazinyl)phenyl]-N'-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- serves as a valuable research tool for understanding the interactions between bioactive molecules and their biological targets. Its structural features, such as the piperazine ring and urea group, may offer insights into the design of new drugs with improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1144072-40-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,4,0,7 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1144072-40:
(9*1)+(8*1)+(7*4)+(6*4)+(5*0)+(4*7)+(3*2)+(2*4)+(1*0)=111
111 % 10 = 1
So 1144072-40-1 is a valid CAS Registry Number.
1144072-40-1Relevant academic research and scientific papers
Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: Discovery of highly potent and selective analogs with improved human microsomal stability
Richard, David J.,Verheijen, Jeroen C.,Curran, Kevin,Kaplan, Joshua,Toral-Barza, Lourdes,Hollander, Irwin,Lucas, Judy,Yu, Ker,Zask, Arie
scheme or table, p. 6830 - 6835 (2010/07/05)
A series of highly potent and selective pyrazolopyrimidine mTOR inhibitors which contain water-solubilizing groups attached to the 6-arylureidophenyl moiety have been prepared. Such derivatives displayed superior potency to those in which these appendages
THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS
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Page/Page column 126, (2009/04/24)
The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein compositions comprising the compounds, and methods for making and using the compounds.
