1144072-79-6Relevant articles and documents
Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: Discovery of highly potent and selective analogs with improved human microsomal stability
Richard, David J.,Verheijen, Jeroen C.,Curran, Kevin,Kaplan, Joshua,Toral-Barza, Lourdes,Hollander, Irwin,Lucas, Judy,Yu, Ker,Zask, Arie
scheme or table, p. 6830 - 6835 (2010/07/05)
A series of highly potent and selective pyrazolopyrimidine mTOR inhibitors which contain water-solubilizing groups attached to the 6-arylureidophenyl moiety have been prepared. Such derivatives displayed superior potency to those in which these appendages